Asymptotic normality of urn models for clinical trials with delayed response

Asymptotic normality of urn models for clinical trials with delayed response
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DOI:
10.3150/bj/1089206406
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发表时间:
2004-06-01
期刊:
影响因子:
1.5
通讯作者:
Zhang, LX
Zhang, LX
中科院分区:
数学2区
文献类型:
--
作者:
Hu, FF;Zhang, LX

文献摘要

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For response-adaptive clinical trials using a generalized Friedman's urn design, we derive the asymptotic normality of the sample fraction assigned to each treatment under staggered entry and delayed response. The rate of convergence and the law of the iterated logarithm are obtained for both the urn composition and the sample fraction. Some applications are also discussed.