Is protein intake associated with bone mineral density in young women?
Is protein intake associated with bone mineral density in young women?
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DOI：
10.3945/ajcn.2009.28728
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发表时间：
2010-05-01
影响因子：
7.1
通讯作者：
Scholes, Delia
中科院分区：
文献类型：
--
作者：
Beasley, Jeannette M.;Ichikawa, Laura E.;Scholes, Delia
背景：绝经前妇女优化骨骼健康的蛋白质摄入范围尚不清楚。蛋白质是骨骼的主要成分，但酸性氨基酸可能促进骨骼吸收。目的：目的是检查基线饮食蛋白和骨密度（BMD）之间的横断面和纵向关联，560名14-40岁的女性在基线时登记在太平洋西北地区的管理护理组织。考虑了蛋白质来源（动物或植物）和参与者特征的作用。设计：在一项调查激素避孕药使用与骨骼健康之间关系的研究中，通过使用半定量食物频率问卷来评估参与者的膳食蛋白质摄入量。使用双能x线骨密度仪测量髋部、脊柱和全身骨密度的年变化。通过线性回归分析和校正混杂因素的广义估计方程，研究了基线蛋白质摄入量（能量百分比）与骨密度之间的横断面和纵向关联。结果：基线时平均（+/- SD）蛋白质摄入量为15.5 +/- 3.2%。在多变量调整后，平均骨密度在蛋白质摄入量的每一分位数是相似的。在横断面分析中，低植物蛋白摄入量与较低的骨密度相关（髋部P = 0.03，脊柱P = 0.10，全身P = 0.04）。在随访期间，每增加一个百分比的蛋白质能量，任何解剖部位的骨密度都没有明显的纵向变化。结论：这项纵向研究的数据表明，较高的蛋白质摄入量对绝经前妇女的骨骼没有不利影响。横断面分析表明，低植物蛋白摄入量与较低的骨密度有关。m J . clinn [2010]；91: 1311 - 6。
Background: The range of protein intakes for optimizing bone health among premenopausal women is unclear. Protein is a major constituent of bone, but acidic amino acids may promote bone resorption.Objective: The objective was to examine cross-sectional and longitudinal associations between baseline dietary protein and bone mineral density (BMD) among 560 females aged 14-40 y at baseline enrolled in a Pacific Northwest managed-care organization. The role of protein source (animal or vegetable) and participant characteristics were considered.Design: Dietary protein intake was assessed by using a semiquantitative food-frequency questionnaire in participants enrolled in a study investigating associations between hormonal contraceptive use and bone health. Annual changes in hip, spine, and whole-body BMD were measured by using dual-energy X-ray absorptiometry. Cross-sectional and longitudinal associations between baseline protein intake (% of energy) and BMD were examined by using linear regression analysis and generalized estimating equations adjusted for confounders.Results: The mean (+/- SD) protein intake at baseline was 15.5 +/- 3.2%. After multivariable adjustment, the mean BMD was similar across each tertile of protein intake. In cross-sectional analyses, low vegetable protein intake was associated with a lower BMD (P = 0.03 for hip, P = 0.10 for spine, and P = 0.04 for whole body). For every percentage increase in the percentage of energy from protein, no significant longitudinal changes in BMD were observed at any anatomic site over the follow-up period.Conclusions: Data from this longitudinal study suggest that a higher protein intake does not have an adverse effect on bone in premenopausal women. Cross-sectional analyses suggest that low vegetable protein intake is associated with lower BMD. Am J Clin Nutr 2010; 91: 1311-6.