Symptoms and quality of life in chronic pancreatitis assessed by structured interview and the EORTC QLQ-C30 and QLQ-PAN26
Symptoms and quality of life in chronic pancreatitis assessed by structured interview and the EORTC QLQ-C30 and QLQ-PAN26
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DOI：
10.1111/j.1572-0241.2005.40859.x
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发表时间：
2005-04-01
影响因子：
9.8
通讯作者：
Johnson, CD
中科院分区：
文献类型：
--
作者：
Fitzsimmons, D;Kahl, S;Johnson, CD
背景和目的：慢性胰腺炎（CP）产生致残症状，需要多年的主要临床干预。生活质量（QoL）评估应成为评估CP治疗和结局的一部分，这一点已达成共识。这些症状和治疗与胰腺癌相似，有经过验证的QoL评估工具。我们的研究的目的是评估使用EORTC生活质量评估系统胰腺癌（EORTC QLQ-C30和QLQ-PAN 26）的CP患者的适当性，并记录重要的问题，影响生活质量在这些patients.Methods：进行结构化的文献综述，以确定目前的方法生活质量在胰腺疾病。要求4个国家（德国、意大利、南非和英国）的66例新诊断或治疗的CP患者完成EORTC QLQ-C30和QLQ-PAN 26。患者被要求审查的内容和结构的工具的适当性，在一个直接采访。标准的心理测试被用来评估的工具的可靠性和有效性。同行评议进行审查结果和适应QLQ-PAN 26的基础上获得的responses.Results：文献综述强调了EORTC QLQ-C30的潜在价值，并确定了缺乏CP特定的工具，这已经得到适当的发展。专家们一致认为EORTC评估系统似乎适用于CP患者。这得到了所有患者的认可。患者还发现了与使用酒精的内疚感和试图戒酒的负担有关的其他问题。QLQ-C30和QLQ-PAN 26的结构效度显示概念相关量表之间有很强的相关性（r>0.6，p <0.05），但黄疸量表的结构效度不高（r>0.70）。
Background and Aims: Chronic pancreatitis (CP) produces disabling symptoms and requires major clinical interventions over a number of years. There is consensus that quality-of-life (QoL) assessment should be part of assessing the treatment and outcome of CP. These symptoms and treatments resemble those of pancreatic cancer, for which there are validated QoL assessment instruments. The aim of our study was to assess the appropriateness of using the EORTC QoL assessment system for pancreatic cancer (the EORTC QLQ-C30 and QLQ-PAN26) for patients with CP, and to document important issues that affect QoL in these patients.Methods: A structured literature review was undertaken to determine current approaches to QoL in pancreatic disease. Sixty-six patients with newly diagnosed or treated CP were asked to complete the EORTC QLQ-C30 and QLQ-PAN26 in four countries (Germany, Italy, South Africa, and United Kingdom). Patients were asked to review the appropriateness of the content and structure of the instruments, during a directed interview. Standard psychometric tests were used to assess the reliability and validity of the instruments. Peer review was undertaken to review findings and adapt the QLQ- PAN26 on the basis of the responses obtained.Results: The literature review highlighted the potential value of the EORTC QLQ-C30 and identified the lack of a CP-specific instrument, which had been appropriately developed. There was overwhelming consensus among experts that the EORTC assessment system appeared suitable for use in CP patients. This was endorsed by all patients. Patients identified additional issues related to guilt about the use of alcohol and the burden of trying to abstain. All but one scale (jaundice) exhibited adequate internal consistency (r>0.70) Construct validity of the QLQ-C30 and QLQ- PAN26 showed strong associations between conceptually related scales (r>0.6, p