Tissue engineering by immobilized growth factors
Tissue engineering by immobilized growth factors
复制标题
DOI：
10.1016/s0928-4931(98)00061-7
复制
发表时间：
1998-12-01
期刊：
影响因子：
--
通讯作者：
Ito, Y
中科院分区：
文献类型：
--
作者：
Ito, Y
Growth factor proteins were covalently immobilized on various matrices to regulate cellular high-dimensional functions. It was shown that insulin and epidermal growth factor stimulated cell growth even after immobilization. Pattern-immobilization of growth factor proteins clearly demonstrated the stimulation by immobilized proteins. In other words, this type of stimulation by non-diffusional growth factors enabled us to regulate tissue formation with artificial biomaterials. The stimulation was enhanced by coimmobilization with adhesion factors. These stimulations by the immobilized growth factors may mimick juxtacrine stimulation of membrane-anchored growth factors such as heparin-binding epidermal growth factor, transforming growth factor-cu, and tumor necrosis factor-alpha. (C) 1998 Elsevier Science S.A. All rights reserved.
