The hypothalamo-pituitary-thyroid (HPT) axis:: A target of nonpersistent ortho-substituted PCB congeners
The hypothalamo-pituitary-thyroid (HPT) axis:: A target of nonpersistent ortho-substituted PCB congeners
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DOI：
10.1093/toxsci/65.1.52
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发表时间：
2002-01-01
影响因子：
3.8
通讯作者：
Hansen, LG
中科院分区：
文献类型：
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作者：
Khan, MA;Lichtensteiger, CA;Hansen, LG
共面多氯联苯（PCBs）对发育中的动物和成年动物造成不良影响。对非平面邻位取代多氯联苯的影响了解较少。我们研究了2种非平面PCB同系物，95（2,3,6-2',5'-五溴环己烷）或101（2,4,5-2',5'-五溴环己烷）和雌二醇对选定内分泌参数的影响。在研究1中，断奶雌性Sprague-Dawley （S-D）大鼠连续2天给予4、8、16和32 mg/kg/天单剂量PCB 95 ip，并在最后一次给药后24 h处死。多氯联苯95暴露引起剂量依赖性(p
Coplanar polychlorinated biphenyls (PCBs) cause adverse effects in developing and adult animals. Less is known about the effects of nonplanar ortho-substituted PCBs. We investigated the effects of 2 nonplanar PCB congeners, 95 (2,3,6-2',5'-penta CB) or 101 (2,4,5-2',5'-penta CB), and estradiol on selected endocrine parameters. In Study 1, weanling female Sprague-Dawley (S-D) rats were given a single dose of PCB 95 ip at 4, 8, 16, and 32 mg/kg/day for 2 consecutive days and killed 24 h after the last dose. PCB 95 exposure caused a dose-dependent (p