Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease
Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease
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DOI：
10.1016/j.parkreldis.2008.10.001
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发表时间：
2009-06-01
影响因子：
4.1
通讯作者：
Pisani, Antonio
中科院分区：
文献类型：
--
作者：
Lunardi, Gianluigi;Galati, Salvatore;Pisani, Antonio
为了评估可能平行帕金森病（PD）疾病进展的多巴胺代谢差异，我们测量了PD患者在不同疾病阶段的脑脊液（CSF）中的多巴胺（DA）及其代谢物：新生（DEN），晚期未出现运动障碍（ADV）和晚期伴有运动障碍（DYS）。DEN患者DA、高香草酸（HVA）和二羟基苯乙酸（DOPAC）均显著高于其他组。DA水平与病程呈负指数相关。ADV组和DYS组HVA/DA比值显著高于DEN组。我们的数据显示，疾病进展会导致早期DA水平大幅下降，随后趋于稳定。相反，在病程较长的患者中，DA周转率的晚期变化（HVA/DA比值增加）被记录下来。我们的研究结果表明，运动障碍的出现可能与DA终端的进一步丧失无关，而是与不同的、异常的DA转换有关。(C) 2008 Elsevier Ltd版权所有。
To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced with dyskinesias (DYS).DA, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in DEN patients compared with other groups. A negative exponential correlation related DA level and disease duration. The HVA/DA ratio was significantly higher in the ADV and DYS group than that found in DEN group.Our data show that disease Progression produces an early large decay of DA levels, followed by a stabilization, On the contrary, a late change in DA turnover (increased HVA/DA ratio) is documented in patients with longer disease duration. Our results Suggest that the appearance of dyskinesia may not be related to a further loss of DA terminals but to a different, abnormal, DA turnover. (C) 2008 Elsevier Ltd. All rights reserved.