Treatment of benign pigmented epidermal lesions by Q-switched ruby laser.
Treatment of benign pigmented epidermal lesions by Q-switched ruby laser.
复制标题
Q开关红宝石激光治疗良性色素性表皮病变。
DOI：
10.1111/j.1365-4362.1993.tb01417.x
复制
发表时间：
1993
影响因子：
3.6
通讯作者：
Anderson,RR
中科院分区：
文献类型：
--
作者：
Taylor,CR;Anderson,RR
背景。皮肤色素沉着障碍是一个常见的问题，它可以导致大量的美容发病率。传统的治疗方法往往无效，有时与进一步的色素沉着、色素沉着或疤痕有关。由于Q开关红宝石激光已被证明可用于治疗纹身，并且在少数情况下可用于治疗表皮黑色素的良性疾病，因此我们决定系统地将这种方式应用于其他良性色素病变。研究人员将9名白人患者的34个良性色素表皮病变（包括小痣、咖啡泡斑和黑痣）暴露在单脉冲的Q开关红宝石激光（694 nm， 40 ns脉冲持续时间）下，激光强度分别为4.5和/或7.5 J/cm2。在一次治疗后，在所有的lentigines和cafeise - au - late斑疹的每个影响处都发生了实质性的清除。经过两次4.5 J/cm2的治疗后，小的痣外溢得到了初步改善，一次7.5 J/cm2的治疗后，更大的痣外溢完全去除了连接或复合痣部分，但cafe - au - lait部分没有改善。1年后观察到背景色素完全恢复。没有疤痕。治疗后，组织学显示角质形成细胞和黑素细胞空泡化，偶尔出现表皮下水泡。这些发现表明，虽然Q开关红宝石激光可能并不完全适用于治疗痣，但它确实提供了一种有效的治疗lentigines和cafeise - au - lait斑。
Background. Disorders of cutaneous pigmentation are a common problem, which can cause substantial cosmetic morbidity. Traditional treatments are often ineffective and sometimes associated with further hyperpigmentation, hypo‐pigmentation, or scarring. Because the Q‐switched ruby laser has proven useful for the treatment of tattoos and, in a small number of cases, benign disorders of the epidermal melanin, we decided to apply this modality systematically to additional benign pigmented lesions.Methods. Thirty‐four benign pigmented epidermal lesions including lentigines, café‐au‐lait macules, and nevi spili in nine white patients were exposed to single pulses of a Q‐switched ruby laser (694 nm, 40 ns pulse duration) at 4.5 and/or 7.5 J/cm2.Results. After one treatment, substantial clearing occurred at each fluence in all lentigines and café‐au‐lait macules. Initial improvement was achieved in a small nevus spilus after two treatments at 4.5 J/cm2, and a larger nevus spilus after one treatment at 7.5 J/cm2with complete removal of the junctional or compound nevi portion but no improvement in the cafe‐au‐lait portion. Complete return of the background pigment was observed by 1 year. There was no scarring. Immediately after treatment, histology revealed vacuolizaton of keratinocytes and melanocytes, and occasional subepidermal blisters.Conclusions. These findings show that while the Q‐switched ruby laser may not be entirely useful for treating nevi spili, it does provide an effective treatment for lentigines and café‐au‐lait macules.