EFFECTS OF DEEP INHALATION DURING EARLY AND LATE ASTHMATIC REACTIONS TO ALLERGEN
EFFECTS OF DEEP INHALATION DURING EARLY AND LATE ASTHMATIC REACTIONS TO ALLERGEN
复制标题
DOI：
10.1164/ajrccm/142.4.822
复制
发表时间：
1990-10-01
期刊：
影响因子：
--
通讯作者：
BRUSASCO, V
中科院分区：
文献类型：
--
作者：
PELLEGRINO, R;VIOLANTE, B;BRUSASCO, V
本文报告了18例对屋尘螨有双相哮喘反应的哮喘患者。通过比较部分（P）和最大（M）流量-容积曲线中40%肺活量时的最大呼气流量（MEF 40）以及DI前后的比气道传导率（SGaw）（SGawDI）来定量深吸气（DI）的效果。在基线时，MEF 40 M/P的比值显著大于1（1.45 ± 0.01）。0.26 SD），而比率SGawDI/SGaw显著不同于1（0.92 ± 0.95）。0.24）。在早期反应期间，MEF 40 M/P和SGawDI/SGaw两者均显著增加至2.66 ± 0.01。0.97和1.96 . ±. 0.47，分别。在晚期反应期间，当FEV 1值与在早期反应期间观察到的值相似时，MEF 40 M/P和SGawDI/SGaw为1.86 ± 0.01。0.46和1.43 .+-。0.29，显著高于基线值，但显著低于早期反应时的值。在9例患者的亚组中获得了相似的结果，晚期反应期间的SGaw值与早期反应期间的SGaw值相似。我们得出结论，DI在早期和晚期哮喘反应中具有不同的效果，这表明气道与实质滞后的比例不同。这可能是由于在晚期反应期间，实质滞后增加（更位于外周的支气管阻塞）或气道滞后减少（显著的气道炎症）所致。
Eighteen asthmatic patients with a biphasic asthmatic reaction to house dust mite were studied. The effect of deep inhalation (DI) was quantitated by comparing the maximal expiratory flow at 40% (MEF40) of vital capacity from partial (P) and maximal (M)flow-volume curves, and specific airways conductance (SGaw) before and after DI (SGawDI). At baseline, the ratio MEF40M/P was significantly larger than unity (1.45 .+-. 0.26 SD), whereas the ratio SGawDI/SGaw was significantly different from unity (0.92 .+-. 0.24). During early phase reaction, both MEF40M/P and SGawDI/SGaw were significantly increased to 2.66 .+-. 0.97 and 1.96 .+-. 0.47, respectively. During late phase reaction, when the FEV1 values were similar to those observed during early phase reaction, MEF40M/P and SGawDI/SGaw were 1.86 .+-. 0.46 and 1.43 .+-. 0.29, respectively, significantly higher than the values at baseline but significantly lower than those during early phase reaction. Similar results were obtained in a subgroup of nine patients with SGaw values during the late phase reaction were similar to those during the early phase reaction. We conclude that DI has a different effect during early and late asthmatic reactions, suggesting a different ratio of airway to parenchymal hysteresis. This may result from an increased parenchymal hysteresis (more peripherally located bronchial obstruction) or a decreased airway hysteresis (prominent airway inflammation) during the late phase reaction.