Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment.

Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment.
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DOI:
10.1111/bph.15638
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发表时间:
2022-03
影响因子:
7.3
通讯作者:
Brierley DI
Brierley DI
中科院分区:
医学2区
文献类型:
--
作者:
Trapp S;Brierley DI

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This review considers the similarities and differences between the physiological systems regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It addresses the questions of whether peripheral and central GLP‐1 sources constitute separate, linked or redundant systems and whether the brain GLP‐1 system consists of disparate sections or is a homogenous entity. This review also explores the implications of the answers to these questions for the use of GLP‐1 receptor agonists as anti‐obesity drugs. This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc
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