Lymphocytic hypophysitis: Light and electron microscopic findings and correlation to clinical appearance
Lymphocytic hypophysitis: Light and electron microscopic findings and correlation to clinical appearance
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DOI：
10.1007/bf02739954
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发表时间：
1998-03-01
影响因子：
4.4
通讯作者：
Saeger, W
中科院分区：
文献类型：
--
作者：
Fehn, M;Sommer, C;Saeger, W
本文报告2500例手术标本中6例淋巴细胞性垂体炎的光镜和电镜观察结果。5例经手术获得，1例尸检获得。光学显微镜检查显示成熟淋巴细胞和浆细胞浸润的胸腺，部分在腺泡，以及在后叶和囊。其余前叶结构正常。淋巴细胞性垂体炎的最后阶段是纤维化，这在所有病例中均可见不同程度的纤维化。浸润主要由T淋巴细胞组成，CK 45 RO和CD 43阳性。免疫细胞化学染色显示不同比例的残留腺垂体细胞，主要观察到催乳素反应细胞和生长激素反应细胞。电镜下可见腺泡破裂，腺垂体细胞受损。少数垂体细胞含有增大的溶酶体或嗜酸细胞的变化。炎症引起的垂体增大导致患者经常在术前诊断为鞍区肿瘤的情况下进行手术。重要的是要确定这种特殊类型的垂体炎，因为需要不同的治疗过程。
Light and electron microscopic findings of six cases of lymphocytic hypophysitis of a collective of 2500 surgical specimens are presented. Five cases were obtained by surgery, one case was obtained from autopsy. Light microscopy revealed an infiltration of mature lymphocytes and plasma cells in the interstitium, partly in the acini, as well as in the posterior lobe and the capsule. The structure of the remaining anterior lobe was normal. The final stage of lymphocytic hypophysitis is fibrosis, which was seen in all cases to varying degrees. The infiltrate consisted mainly of T-lymphocytes, being positive for CK 45 RO and CD 43. Immunocytochemical staining revealed different proportions of residual adenohypophyseal cells, Mainly prolactin reactive cells were observed as were growth hormone reactive cells. By electron microscopy same ruptured acini and damaged adenohypophyseal cells could be seen. Few pituitary cells contained enlarged lysosomal bodies or oncocytic changes. Inflammation causing enlargement of the pituitary leads to patients often being operated under the preoperative diagnosis of a tumor of the sellar region. It is important to identify this special type of hypophysitis, as a different course of treatment is required.