The role of HoxA11 and HoxA13 in the evolution of novel fin morphologies in a representative batoid (Leucoraja erinacea).
The role of HoxA11 and HoxA13 in the evolution of novel fin morphologies in a representative batoid (Leucoraja erinacea).
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DOI：
10.1186/s13227-017-0088-4
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发表时间：
2017
期刊：
影响因子：
4.1
通讯作者：
Crow KD
中科院分区：
文献类型：
--
作者：
Barry SN;Crow KD
蝙蝠类具有独特的身体结构和衍生的鳍形态，例如与头部融合的前展胸鳍，或用于溜冰鞋(Rajidae)改进游泳技术的远端延伸的骨盆前鳍叶。小溜冰(银合欢)，展示了这两种独特的鳍形态。这些鳍的修改并不存在于典型的鲨鱼身体计划中，而且人们对它们的发育机制知之甚少。最近的一项研究发现了一种新的顶端外胚层脊(AER)，它与小冰鞋胸鳍的发育有关，但后部HoxA基因在冰鞋鳍发育过程中的作用并不明显。我们首次提出了在新的AER结构域中表达HoxA(HoxA11和HoxA13)的证据，这些新结构域与具有代表性的蝙蝠(L.erinacea)三种新的鳍形态的发育有关。我们发现HoxA13的表达与最近描述的新的胸鳍AER相关，而HoxA11的表达与我们在这里描述的一个新的AER结构域有关。我们发现HoxA11和HoxA13都在扣环中表达，而HoxA11在腹鳍和扣环中表达，而HoxA13仅在雄性扣环的发育中表达。最后，HoxA11的表达与成对鳍的鳍射线发育有关。总体而言，这些结果表明，后部HoxA基因在典型蝙蝠成对鳍的形态进化中起着重要作用。这些数据表明，蝙蝠利用了一个独特的HOX密码，其中后部的HoxA基因表现出不同的表达模式，这可能与新的鳍形态的规范有关。本文的在线版本(10.1186/s13227-0170088-4)包含补充材料，可供授权用户使用。
Batoids exhibit unique body plans with derived fin morphologies, such as the anteriorly expanded pectoral fins that fuse to the head, or distally extended anterior pelvic fin lobes used for a modified swimming technique utilized by skates (Rajidae). The little skate (Leucoraja erinacea), exhibits both of these unique fin morphologies. These fin modifications are not present in a typical shark body plan, and little is known regarding the mechanisms underlying their development. A recent study identified a novel apical ectodermal ridge (AER) associated with the development of the anterior pectoral fin in the little skate, but the role of the posterior HoxA genes was not featured during skate fin development. We present the first evidence for HoxA expression (HoxA11 and HoxA13) in novel AER domains associated with the development of three novel fin morphologies in a representative batoid, L. erinacea. We found HoxA13 expression associated with the recently described novel AER in the anterior pectoral fin, and HoxA11 expression in a novel AER domain in the anterior pelvic fin that we describe here. We find that both HoxA11 and HoxA13 are expressed in claspers, and while HoxA11 is expressed in pelvic fins and claspers, HoxA13 is expressed exclusively in developing claspers of males. Finally, HoxA11 expression is associated with the developing fin rays in paired fins. Overall, these results indicate that the posterior HoxA genes play an important role in the morphological evolution of paired fins in a representative batoid. These data suggest that the batoids utilize a unique Hox code, where the posterior HoxA genes exhibit distinct expression patterns that are likely associated with specification of novel fin morphologies. The online version of this article (10.1186/s13227-017-0088-4) contains supplementary material, which is available to authorized users.
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影响因子：
64.8
作者：
Freitas, Renata;Zhang, GuangJun;Cohn, Martin J.
通讯作者：
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影响因子：
4.1
作者：
Archambeault, Sophie;Taylor, Julia Ann;Crow, Karen D.
通讯作者：
Crow, Karen D.
DOI：
10.1002/ar.20719
发表时间：
2008-09-01
影响因子：
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通讯作者：
Heppleston, Audrey C.
影响因子：
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作者：
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通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
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