Would blockage of cytokines improve the outcome of pancreatic islet transplantation?
Would blockage of cytokines improve the outcome of pancreatic islet transplantation?
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DOI：
10.1016/j.mehy.2005.08.057
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发表时间：
2006-01-01
影响因子：
4.7
通讯作者：
Larijani, B
中科院分区：
文献类型：
--
作者：
Amoli, MM;Larijani, B
据估计，高达 60% 的胰岛组织在移植后的最初几天内发生细胞凋亡。这强烈表明，胰岛移植后除了同种异体抗原特异性免疫反应之外，还涉及炎症事件，导致移植物部分破坏。包括IL-1β、TNF-α和IFN-γ在内的炎症细胞因子与自身免疫性糖尿病期间的胰岛β细胞死亡和功能丧失有关，并且似乎也参与了自身免疫性糖尿病的早期折腾。 胰岛移植中的胰岛质量。原位释放的炎症细胞因子和自由基可能导致胰岛移植后胰岛细胞凋亡和功能损伤以及移植失败。可以推测，利用细胞因子阻断来防止移植胰岛的破坏可能有助于改善胰岛移植的结果。基于这一假设，已经提出了几种方法来检查炎症阻断对胰岛存活和功能性胰岛质量的影响。需要进一步研究以确定阻断胰岛移植中细胞因子诱导的损伤的最有效方法。 (c) 2005 Elsevier Ltd. 保留所有权利。
It has been estimated that up to 60% of pancreatic islet tissue undergoes apoptosis within the first several days post-transplantation. This strongly suggests the involvement of an inflammatory event other than alloantigenspecific immune reaction following islet transplantation which contributes to partial destruction of grafts.Inflammatory cytokines including IL-1 beta, TNF-alpha and IFN-gamma are implicated in the pancreatic islet beta-cell death and functional loss during autoimmune diabetes and also seem to be involved in early toss of islet mass in islet transplantation. Inflammatory cytokines and free oxygen radicals released in situ could cause apoptosis and the functional impairment of islets after islet transplantation and graft failure.It can be hypothesized that preventing destruction of transplanted islets using cytokine blockade could be helpful in improving islet transplantation outcome. Several approaches have been made based on this hypothesis to examine the effect of inflammatory blockade on the islets survival and functional islet mass.Further investigations are required to identify most efficient way for block of cytokine-induced damage in pancreatic islets transplantation. (c) 2005 Elsevier Ltd. All rights reserved.