Decreased Temporomandibular Joint Range of Motion in a Model of Early Osteoarthritis in the Rabbit.
Decreased Temporomandibular Joint Range of Motion in a Model of Early Osteoarthritis in the Rabbit.
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DOI：
10.1016/j.joms.2015.03.042
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Almarza AJ
中科院分区：
文献类型：
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作者：
Henderson SE;Tudares MA;Tashman S;Almarza AJ
通过研究损伤或疾病对颞下颌关节（TMJ）运动的影响，分析下颌生物力学有助于理解骨关节炎（TMJ- oa）等颞下颌关节疾病（TMJDs）的机制。本研究的目的是确定兔单侧夹板改变闭塞引起的轻度TMJ-OA退行性变的功能运动学意义。通过单侧磨牙夹板机械诱导兔颞下颌关节改变咬合（n = 3）。使用三维骨骼运动学评估TMJ运动两次，一次是在夹板放置6周之前，一次是在夹板移除后，允许3天恢复。跟踪髁突与窝的相对运动和门牙之间的距离。在门牙和髁突和窝之间的关节间隙观察到关节活动范围的总体减少。切牙左右移动从7.0±0.5 mm减少到6.2±0.5 mm，前后移动从5.5±2.2 mm减少到4.6±0.8 mm，上下移动从13.3±1.8 mm减少到11.6±1.4 mm （P < 0.05）。工作髁与窝点之间的最大距离从3.6±0.8 mm减小到3.1±0.6 mm，平衡髁从2.8±0.4 mm减小到2.5±0.4 mm （P < 0.05）。两个髁的前后方向均出现最大的下降。确定髁突运动的变化可能有助于更好地了解TMJ-OA发展的早期预测因素，并确定症状何时成为慢性、不可逆转的问题。
Analysis of mandibular biomechanics could help with understanding the mechanisms of temporomandibular joint (TMJ) disorders (TMJDs), such as osteoarthritis (TMJ-OA), by investigating the effects of injury or disease on TMJ movement. The objective of the present study was to determine the functional kinematic implications of mild TMJ-OA degeneration caused by altered occlusion from unilateral splints in the rabbit. Altered occlusion of the TMJ was mechanically induced in rabbits by way of a unilateral molar dental splint (n = 3). TMJ motion was assessed using 3-dimensional (3D) skeletal kinematics twice, once before and once after 6 weeks of splint placement with the splints removed, after allowing 3 days of recovery. The relative motion of the condyle to the fossa and the distance between the incisors were tracked. An overall decrease in the range of joint movement was observed at the incisors and in the joint space between the condyle and fossa. The incisor movement decreased from 7.0 ± 0.5 mm to 6.2 ± 0.5 mm right to left, from 5.5 ± 2.2 mm to 4.6 ± 0.8 mm anterior to posterior, and from 13.3 ± 1.8 mm to 11.6 ± 1.4 mm superior to inferior (P < .05). The total magnitude of the maximum distance between the points on the condyle and fossa decreased from 3.6 ± 0.8 mm to 3.1 ± 0.6 mm for the working condyle and 2.8 ± 0.4 mm to 2.5 ± 0.4 mm for the balancing condyle (P < .05). The largest decreases were seen in the anteroposterior direction for both condyles. Determining the changes in condylar movement might lead to a better understanding of the early predictors in the development of TMJ-OA and determining when the symptoms become a chronic, irreversible problem.