The mammalian germline as a pluripotency cycle
The mammalian germline as a pluripotency cycle
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DOI：
10.1242/dev.091603
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发表时间：
2013-06-15
期刊：
影响因子：
4.6
通讯作者：
Smith, Austin
中科院分区：
文献类型：
--
作者：
Leitch, Harry G.;Smith, Austin
幼稚多能性是指调节胚胎中的单细胞产生所有体细胞和生殖细胞类型的能力。只有生殖细胞-传统上被认为是单能的-可以通过受精循环自然地重新获得多能性。此外，原始生殖细胞表达，并似乎是功能上依赖于，转录因子，使多能状态。我们假设生殖细胞需要多能性因子来控制一个非限制性表观基因组。因此，它们具有潜在的潜能，如在体外致畸致癌或直接转化为多能干细胞中所表现的。因此，我们认为，存在一个完整的多能性循环，幼稚的早期外胚层和潜伏的种系，这是由一个共享的转录因子网络。
Naive pluripotency refers to the capacity of single cells in regulative embryos to engender all somatic and germline cell types. Only germ cells - conventionally considered to be unipotent - can naturally re-acquire pluripotency, by cycling through fertilisation. Furthermore, primordial germ cells express, and appear to be functionally dependent upon, transcription factors that characterise the pluripotent state. We hypothesise that germ cells require pluripotency factors to control a de-restricted epigenome. Consequently, they harbour latent potential, as manifested in teratocarcinogenesis or direct conversion into pluripotent stem cells in vitro. Thus, we suggest that there exists an unbroken cycle of pluripotency, naive in the early epiblast and latent in the germline, that is sustained by a shared transcription factor network.