Mechanism underlying Polygonum capitatum effect on Helicobacter pylori-associated gastritis based on network pharmacology
Mechanism underlying Polygonum capitatum effect on Helicobacter pylori-associated gastritis based on network pharmacology
复制标题
基于网络药理学探讨头花蓼治疗幽门螺杆菌相关性胃炎的机制
DOI：
10.1016/j.bioorg.2021.105044
复制
发表时间：
2021-06-24
影响因子：
5.1
通讯作者：
Mo, Fei
中科院分区：
文献类型：
--
作者：
Song, Xiaohan;He, Yun;Mo, Fei
幽门螺杆菌感染是一种常见疾病，可引起幽门螺杆菌相关性胃炎（HAG）、消化性溃疡和胃癌。首蓼作为一种传统中药，具有清热解毒止痛、活血化瘀的功效，在防治复杂疾病和慢性疾病方面具有独特的优势。为了探索PC对HAG的分子机制，本研究收集了活性化合物的预测靶点，通过STRING数据库进行功能分析，收集HAG差异表达基因，并通过Cluego对预测靶点与胃炎差异表达基因的交集进行KEGG富集分析。结果表明，PC主要通过影响I Kappa B α、NF-Kappa B p65、p38MAPK和ERK1/2的磷酸化以及NF-Kappa B p65和p-p38MAPK的核转位来起作用，这已被体内和体外实验证实。这些结果表明，PC可能通过多种靶点和途径作用于HAG，并在HAG的治疗过程中发挥关键作用。
Helicobacter pylori (H. pylori) infection is a common disease that can cause H. pylori-associated gastritis (HAG), peptic ulcers, and gastric cancer. As a traditional Chinese medicine, Polygonum capitatum (PC) manifests its unique advantages in the prevention and treatment of complex diseases and chronic diseases, due to its ability to clear heat, detoxify and relieve pain, promote blood circulation, and remove blood stasis. In order to explore the molecular mechanism of PC for HAG, the study collected the predicted targets of active compounds, conducted functional analysis by the STRING database, collected HAG differential expression genes, and conducted KEGG enrichment analysis on the intersection of predicted targets and differential expression genes of gastritis by Cluego. The results show that PC works mainly by affecting phosphorylation of I Kappa B alpha, NF-Kappa B p65, p38MAPK, and ERK1/2 and nuclear transposition of NF-Kappa B p65 and p-p38MAPK, which has been proved by in vivo and in vitro experiments. These results suggest that PC may act on HAG with multiple targets and pathways, and play a key role in the process of HAG treatment.