Hippocampus, time, and memory.
Hippocampus, time, and memory.
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海马、时间和记忆。
DOI：
10.1037//0735-7044.98.1.3
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发表时间：
1984
影响因子：
1.9
通讯作者：
Olton,DS
中科院分区：
文献类型：
--
作者：
Meck,WH;Church,RM;Olton,DS
五项实验确定了海马损伤对时间事件的时间和记忆的影响。挪威大鼠（N = 20）接受训练以区分持续时间（2 或 8 秒）和速率（2 或 16 周期/秒）不同的听觉信号。 Ss获得辨别力后，呈现出中等持续时间和速率的信号。然后 Ss 接受穹窿伞损伤或对照手术。术后，通过差值阈值（DL）测量的持续时间和速率辨别的准确性不受病变影响，但主观平等的点因病变而转移到更短的持续时间和更慢的速率。具有病变的 Ss 和具有控制操作的 Ss 都显示出从训练中使用的听觉信号到视觉信号的持续时间和速率的跨模式转移。当在信号结束和响应机会之间施加 5 秒的延迟时，受损的 Ss 会因延迟的增加而选择性受损（通过 DL 的增加来衡量）。当采用峰值程序时，对照的最大响应率大约在预定强化时间（20秒），但受损Ss的最大响应率早于强化时间。当在信号中施加 5 秒间隙时，对照将间隙之前和之后的信号持续时间相加，而受损的 Ss 没有显示间隙之前的信号持续时间的保留。病变损害了 8 臂径向迷宫中的空间工作记忆。（51 参考）（PsycINFO 数据库记录 (c) 2016 APA，保留所有权利）
Five experiments determined the effects of hippocampal damage on timing and the memory for temporal events. Norway rats (N= 20) were trained to discriminate between auditory signals that differed in both duration (2 or 8 sec) and rate (2 or 16 cycles/sec). After Ss acquired the discrimination, signals with intermediate durations and rates were presented. Ss then received either fimbria-fornix lesions or control operations. Postoperatively, the accuracy of duration and rate discriminations as measured by the difference limen (DL) was unaffected by the lesion, but the point of subjective equality was shifted to a shorter duration and a slower rate by the lesion. Both Ss with lesions and Ss with control operations showed cross-modal transfer of duration and rate from the auditory signals used in training to visual signals. When a 5-sec delay was imposed between the end of a signal and the opportunity to respond, lesioned Ss were selectively impaired by the addition of the delay as measured by an increase in the DL. When a peak procedure was employed, the maximum response rate of controls was approximately at the time of scheduled reinforcement (20 sec), but the maximum response rate of lesioned Ss was earlier than the time of reinforcement. When a 5-sec gap was imposed in the signal, controls summed the signal durations before and after the gap, whereas lesioned Ss showed no retention of the signal duration prior to the gap. Lesions impaired spatial working memory in an 8-arm radial maze.(51 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)