Whole body oxygenation using intraperitoneal perfusion of fluorocarbons.
Whole body oxygenation using intraperitoneal perfusion of fluorocarbons.
复制标题
使用碳氟化合物腹腔灌注进行全身氧合。
DOI：
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发表时间：
1984
影响因子：
9.8
通讯作者：
P. Salt
中科院分区：
文献类型：
--
作者：
N. Faithfull;J. Klein;H. van der Zee;P. Salt
进行了一项初步研究，以评估通过腹膜灌注含全氟化碳的输氧血液替代品 20% Fluosol-DA，在完整动物中增加动脉氧分压并降低动脉二氧化碳分压的可行性。使用气泡充氧器和循环泵对兔子进行灌注，以 25 ml min-1 的速率输送 Fluosol。对照血气测量在 0.5 至（如果动物没有严重缺氧）0.16 之间的各种 FIO2 下进行。在 Fluosol 腹腔灌注期间重复测量。在所有 FIO2 值下，PaO2 均显着增加（P 小于 0.05）。如果动物不缺氧（PaO2 大于 10 kPa），则 PaCO2 显着下降（P 小于 0.05）。
A preliminary study was undertaken to assess the feasibility of increasing the arterial oxygen tension, and decreasing the arterial carbon dioxide tension, in intact animals, by means of peritoneal perfusion with the perfluorocarbon-containing, oxygen-transporting blood substitute, 20% Fluosol-DA. Perfusion was carried out in rabbits using a bubble oxygenator and circulator pump, delivering Fluosol at a rate of 25 ml min-1. Control blood-gas measurements were carried out at various FIO2 between 0.5 and (if the animal was not severely hypoxic) 0.16. The measurements were repeated during the intraperitoneal perfusion of Fluosol. At all values of FIO2, significant increases in PaO2 were seen (P less than 0.05). Significant decreases of PaCO2 (P less than 0.05) were seen if the animals were not hypoxic (PaO2 greater than 10 kPa).