Absence of a relationship between joint space narrowing and osteophyte formation in early knee osteoarthritis among Japanese community-dwelling elderly individuals: A cross-sectional study
Absence of a relationship between joint space narrowing and osteophyte formation in early knee osteoarthritis among Japanese community-dwelling elderly individuals: A cross-sectional study
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DOI：
10.1080/14397595.2016.1232775
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发表时间：
2017-07
影响因子：
2.2
通讯作者：
Daigo Komatsu;Y. Hasegawa;T. Kojima;T. Seki;Yoshitoshi Higuchi;N. Ishiguro
中科院分区：
文献类型：
--
作者：
Daigo Komatsu;Y. Hasegawa;T. Kojima;T. Seki;Yoshitoshi Higuchi;N. Ishiguro
摘要目的：膝关节骨关节炎的X线表现为关节间隙变窄和骨赘形成，二者并不一定是同步的过程。我们评估了内侧最小关节间隙宽度(MJSW)与骨赘形成的关系。方法：我们对1050名(男性424人，女性626人；平均年龄64.9岁)进行了一项回顾性研究，这些人在2011至2013年间接受了膝关节X光检查。用自动化软件测量mJSW和胫骨骨赘面积(OF)。将MJSW范围细分为三个等级，并比较其中的OF、MJSW和生活质量(QOL)。评价Of与mJSw的相关性。结果：在女性中，OF最大，且仅在最低三分位组与MJSW值相关。最低mJSW组患者的生活质量低于其他两组，疼痛程度高于其他两组。根据我们的广义相加模型和受试者工作特征曲线分析，女性的mJSW值明显为3.5 mm，男性没有明显的临界点。结论：在女性中，在3.5 mm的临界值以下，OF与mJSW相关。OA症状，即身体功能损害和疼痛，随着mJSW降低到临界值以下而显著增加。
Abstract Objectives: Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. Methods: We conducted a retrospective study of 1050 individuals (424 males; 626 females; mean age 64.9 years) who underwent knee radiography as part of a health screening program, between 2011 and 2013. mJSW and tibial osteophyte area (OF) were quantified using automated software. The mJSW range was subdivided into tertiles, and OF, mJSW, and quality of life (QOL) were compared among them. Correlation between OF and mJSW was evaluated. Results: In females, OF was largest and correlated with mJSW only in the lowest tertile group. Patients in the lowest mJSW tertile group had a lower QOL and higher pain than those in the other two groups. Based on our generalized additive models and a receiver operating characteristic curve analysis, an mJSW cutoff point of 3.5 mm was apparent in females, with no significant cutoff identified in males. Conclusions: OF correlates with mJSW below a cutoff value of about 3.5 mm in females. OA symptoms, namely physical function impairment and pain, increases significantly as mJSW decreases below the cutoff.