Epithelial-mesenchymal transition in ovarian cancer
Epithelial-mesenchymal transition in ovarian cancer
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DOI：
10.1016/j.canlet.2009.09.017
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发表时间：
2010-05-01
期刊：
影响因子：
9.7
通讯作者：
Salzet, Michel
中科院分区：
文献类型：
--
作者：
Vergara, Daniele;Merlot, Benjamin;Salzet, Michel
卵巢癌是一种高度转移性疾病，是妇科恶性肿瘤死亡的主要原因。因此，了解与卵巢癌转移相关的分子变化有助于确定新的治疗干预的靶点。上皮细胞向间充质细胞的转化在胚胎发育和肿瘤侵袭和转移中都起着关键作用。上皮-间充质转化(EMT)过程中的细胞失去上皮形态，重组细胞骨架，并通过上调和下调一些分子，包括紧密连接蛋白和间充质标志物，获得一种运动性表型。在卵巢癌中，EMT由转化生长因子-β(TGF-β)、表皮生长因子(EGF)、肝细胞生长因子(HGF)和内皮素-1(ET-1)诱导。这些细胞通路的改变使它们成为卵巢癌治疗的有用靶点。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Ovarian cancer is a highly metastatic disease and the leading cause of death from gynecologic malignancy. Hence, and understanding of the molecular changes associated with ovarian cancer metastasis could lead to the identification of targets for novel therapeutic interventions.The conversion of an epithelial cell to a mesenchymal cell plays a key role both in the embryonic development and cancer invasion and metastasis. Cells undergoing epithelial-mesenchymal transition (EMT) lose their epithelial morphology, reorganize their cytoskeleton and acquire a motile phenotype through the up- and down-regulation of several molecules including tight and adherent junctions proteins and mesenchymal markers.EMT is believed to be governed by signals from the neoplastic microenvironment including a variety of cytokines and growth factors. In ovarian cancer EMT is induced by transforming growth factor-beta (TGF-beta), epidermal growth factor (EGF), hepatocyte growth factor (HGF) and endothelin-1 (ET-1). Alterations in these cellular pathways candidate them as useful target for ovarian cancer treatment. (C) 2009 Elsevier Ireland Ltd. All rights reserved.