Beneficial effects of a Ca2+ sensitizer, MCI-154, on the myocardial oxygen consumption-cardiac output relation in patients with left ventricular dysfunction after myocardial infarction: comparison with dobutamine and phosphodiesterase inhibitor.
Beneficial effects of a Ca2+ sensitizer, MCI-154, on the myocardial oxygen consumption-cardiac output relation in patients with left ventricular dysfunction after myocardial infarction: comparison with dobutamine and phosphodiesterase inhibitor.
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Ca2 增敏剂 MCI-154 对心肌梗死后左心室功能障碍患者心肌耗氧量-心输出量关系的有益影响：与多巴酚丁胺和磷酸二酯酶抑制剂的比较。
DOI：
10.1016/s0002-8703(97)70221-7
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发表时间：
1997
影响因子：
4.8
通讯作者：
M. Yokoyama
中科院分区：
文献类型：
--
作者：
H. Takaoka;M. Takeuchi;K. Hata;Y. Hayashi;M. Mori;H. Yamakawa;K. Yamaguchi;M. Yokoyama
尽管传统的正性肌力药物（例如儿茶酚胺）会增加心肌耗氧量，但新开发的正性肌力药物（一种Ca 2+增敏剂）可能能够增加心输出量，同时减少心肌耗氧量。通过右心导管检查，我们评估了冠心病患者在β-肾上腺素能受体刺激（多巴酚丁胺，n = 15）、磷酸二酯酶抑制（E-1020，n = 10）和钙离子增敏（MCI-154，n = 17）期间每单位心输出量增加的心肌耗氧量增加比率。多巴酚丁胺增加心输出量和心肌耗氧量。E-1020增加心输出量，但不改变心肌耗氧量。MCI-154增加心输出量并降低心肌耗氧量。多巴酚丁胺和E-1020增加心输出量的氧气成本与右旋糖酐输注不同（n = 18）;相反，MCI-154的氧气成本显著较小。因此，新开发的钙离子增敏剂MCI-154可能对心力衰竭的治疗有益。(Am Heart J 1997;133：283-9.）
Although conventional inotropic agents such as catecholamines increase myocardial oxygen consumption, a newly developed inotropic agent, a Ca2+sensitizer, may be able to increase cardiac output with less myocardial oxygen consumption. By using right-side heart catheterization, we assessed the ratio of the increase in myocardial oxygen consumption per unit increase in cardiac output during β-adrenergic receptor stimulation (dobutamine, n = 15), phosphodiesterase inhibition (E-1020, n = 10), and Ca2+sensitization (MCI-154, n = 17) in patients with coronary artery disease. Dobutamine increased cardiac output and myocardial oxygen consumption. E-1020 increased cardiac output but did not change myocardial oxygen consumption. MCI-154 increased cardiac output and decreased myocardial oxygen consumption. The oxygen cost of increasing cardiac output with dobutamine and with E-1020 was different from that with dextran infusion ( n = 18); in contrast, the oxygen cost with MCI-154 was significantly smaller. Thus a newly developed Ca2+sensitizer, MCI-154, may be beneficial for the treatment of heart failure. (Am Heart J 1997;133:283-9.)
暴露于钙敏化剂 EMD 53998 的缺氧心肌细胞出现负松弛性和异常的钙处理。
影响因子：
5
作者：
Webster,KA;Bodi,I;McNamara,JP;Tracy,M;Discher,DJ;Bishopric,NH
通讯作者：
Bishopric,NH
DPI 201-106 对对照和肌病人类心脏的完整和带皮小梁中肌丝对 Ca2+ 敏感性的不同影响。
DOI：
10.1172/jci113769
发表时间：
1988
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Hajjar,RJ;Gwathmey,JK;Briggs,GM;Morgan,JP
通讯作者：
Morgan,JP
改变肌原纤维对 Ca 的反应作为正性肌力机制。
影响因子：
37.8
作者：
Blinks,JR;Endoh,M
通讯作者：
Endoh,M