Serum alkaline phosphatase isoenzyme patterns in patients with chronic renal failure.
Serum alkaline phosphatase isoenzyme patterns in patients with chronic renal failure.
复制标题
慢性肾功能衰竭患者的血清碱性磷酸酶同工酶模式。
DOI：
10.1016/0009-8981(77)90042-0
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
A. Pierides
中科院分区：
文献类型：
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作者：
A. Skillen;A. Pierides
1.用丙烯酰胺凝胶电泳法对204例慢性肾功能衰竭患者血清碱性磷酸酶（ALP）同工酶进行了长达18个月的检测。2.在血清ALP活性升高的患者中，骨同工酶是主要原因。即使总血清ALP活性保持在正常参考范围内，骨同工酶量增加也应该表明骨病理学。3.肠碱性磷酸酶是15%定期血液透析患者和10%未透析的尿毒症患者的主要血清碱性磷酸酶。在血清碱性磷酸酶活性正常的患者中，可检测到的肠碱性磷酸酶的总发生率为36%。4.对于那些血清ALP活性在研究期间发生显著变化的患者，这通常反映了骨同工酶量的变化。在研究期间，血清中肠同工酶异常的患者通常血清ALP活性变化不大。
1. Using acrylamide gel electrophoresis the serum alkaline phosphatase (ALP) isoenzyme patterns of 204 patients with chronic renal failure have been examined for periods up to 18 months in length. 2. Of those with elevated serum ALP activity the bone isoenzyme was largely responsible. The presence of increasing amounts of the bone isoenzyme even if the total serum ALP activity remains within the normal reference range should also indicate bone pathology. 3. Intestinal alkaline phosphatase was the major serum alkaline phosphatase in 15% of patients on regular haemodialysis and 10% of uraemic patients not on dialysis. The overall incidence of detectable intestinal alkaline phosphatase in those with normal serum ALP activity was 36%. 4. With those patients whose serum ALP activity changed significantly during the investigation this usually reflected changes in the amount of the bone isoenzyme. Patients with abnormal amounts of the intestinal isoenzymes in their serum usually showed little variation in serum ALP activity over the period of the study.