Role of the Serrated Pathway in Colorectal Cancer Pathogenesis
Role of the Serrated Pathway in Colorectal Cancer Pathogenesis
复制标题
DOI：
10.1053/j.gastro.2009.12.066
复制
发表时间：
2010-06-01
期刊：
影响因子：
29.4
通讯作者：
Whitehall, Vicki
中科院分区：
文献类型：
--
作者：
Leggett, Barbara;Whitehall, Vicki
“锯齿状肿瘤途径”描述了锯齿状息肉（包括无蒂锯齿状腺瘤和传统锯齿状腺瘤）向结直肠癌的进展。在过去的15年中，对这一途径的认识导致了我们对结直肠癌分子基础的理解的范式转变和临床实践的重大变化。这些发现与通过结肠镜监测计划预防间歇期癌症特别相关，这是结肠镜医师的一个重要问题。在过去，所有锯齿状息肉都被简单地归类为增生性息肉，并被认为没有恶性潜力。对这一观点的重新评价主要是由于对增生性息肉病恶性潜能的认识不断提高。
The "serrated neoplastic pathway" describes the progression of serrated polyps, including sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The recognition of this pathway during the last 15 years has led to a paradigm shift in our understanding of the molecular basis of colorectal cancer and significant changes in clinical practice. These findings are particularly relevant to prevention of interval cancers through colonoscopy surveillance programs-an important issue for colonoscopists. In the past, all serrated polyps were classified simply as hyperplastic polyps and were considered to have no malignant potential. Reappraisal of this view was largely driven by increasing recognition of the malignant potential of hyperplastic polyposis.