Azide trapping of metallocarbenes: generation of reactive C-acylimines and domino trapping with nucleophiles
Azide trapping of metallocarbenes: generation of reactive C-acylimines and domino trapping with nucleophiles
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DOI：
10.1039/c4ra06044j
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发表时间：
2014-07
期刊：
影响因子：
3.9
通讯作者：
Tina M. Bott;B. Atienza;F. West
中科院分区：
文献类型：
--
作者：
Tina M. Bott;B. Atienza;F. West
叠氮系缚的重氮羰基化合物经过铜催化转化为瞬态c -酰基胺。这些反应性中间体可以被各种碳亲核试剂捕获，在一次转化中产生复杂的3-吲哚酮框架，包括那些相邻的四取代碳中心。
Azide-tethered diazocarbonyl compounds undergo copper-catalyzed conversion to transient C-acylimines. These reactive intermediates can be trapped with a variety of carbon nucleophiles, giving rise to complex 3-indolinone frameworks, including those with adjacent tetra-substituted carbon centers, in a single transformation.