Ovarian cysts in MRL/MpJ mice originate from rete ovarii
Ovarian cysts in MRL/MpJ mice originate from rete ovarii
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DOI：
10.1111/j.1439-0264.2006.00728.x
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发表时间：
2007-06-01
期刊：
影响因子：
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通讯作者：
Endoh, D.
中科院分区：
文献类型：
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作者：
Kon, Y.;Konno, A.;Endoh, D.
在 1 岁以上的 MRL 小鼠中，但在 C57BL/6 小鼠中没有，卵巢有肉眼可见的单侧或双侧囊肿。出生后，所有 MRL 小鼠在 8 个月大时都会出现卵巢囊肿。包括凝集素组织化学在内的光学显微镜观察表明，囊肿有时包括位于肺门区域的乳头状瘤组织，与卵巢网系统相似，但与卵泡不同。囊肿上排列有纤毛和非纤毛两种上皮细胞，两种细胞类型均具有许多向不同方向突出的微绒毛，并在囊腔内随机分支。这些特征表明，MRL 小鼠中发生的卵巢囊肿主要源自卵巢网。在所有 C3H 小鼠和 MRL 小鼠中，在 8 月龄时组织学上检测到来源于卵巢网的囊肿，在 ICR、AKR、CBA/N 和 ddY 小鼠中发生率不同，而在 C57L/6、DBA/2、BALB 和 A/J 小鼠中则没有。然而，对卵巢囊肿最大直径的测量表明，MRL 小鼠通常拥有肉眼可见的最大囊肿。这是该近交系中首次报道卵巢囊肿，表明 MRL 小鼠卵巢囊肿的发生和发展稳定。
In MRL mice aged more than 1 year, but not in C57BL/6 mice, ovaries had grossly visible cysts presenting unilaterally or bilaterally. Postnatally, all MRL mice developed ovarian cysts by 8 months of age. Observations by light microscopy, including lectin histochemistry, indicated that the cysts sometimes included papillomatous tissues located at the hilar region and were similar to the rete ovarii system, but not to follicles. Two types of epithelial cells, ciliated and non-ciliated, were arranged on the cysts, in which both cell types had many microvilli projecting in various directions and random ramifications in the cystic lumen. These characteristics suggest that ovarian cysts developing in MRL mice originate mostly from the rete ovarii. Cysts derived from the rete ovarii at 8 months of age were histologically detected in all C3H mice as well as MRL mice, with variable incidence in ICR, AKR, CBA/N and ddY, and none in C57L/6, DBA/2, BALB and A/J mice. However, measurement of the maximum diameters of the ovarian cysts indicated that MRL mice regularly possessed the largest cysts visible to the naked eye. This is the first report of ovarian cysts in this inbred strain, suggesting that ovarian cysts in MRL mice appear with stable incidence and development.