Evaluation of an artifact reduction strategy for electrically evoked auditory steady-state responses: Simulations and measurements
Evaluation of an artifact reduction strategy for electrically evoked auditory steady-state responses: Simulations and measurements
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DOI：
10.1016/j.jneumeth.2017.12.025
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发表时间：
2018-02-15
影响因子：
3
通讯作者：
Baumann, Uwe
中科院分区：
文献类型：
--
作者：
Bahmer, Andreas;Pieper, Sabrina;Baumann, Uwe
背景资料：电诱发稳态反应（EASSR）记录是对听觉系统连续电刺激后神经元反应强度的测量。为了抑制由脑内电刺激产生的大的电伪影，已经提出了复杂的伪影减少处理策略（“Hofmann程序”）（Hofmann和Wouters，2010）。到目前为止，EASSR记录与伪影减少程序的报告，只有在人工耳蜗植入（CI）的用户植入的Cobalar设备（Macquarie，澳大利亚）。新方法：在这里，我们证明了应用霍夫曼程序的CI用户植入MED-EL（因斯布鲁克，奥地利）设备。为了证明潜在的局限性的程序，我们计算了离散时间傅立叶变换（DTFT）的各种脉冲模式，可用于EASSR.Results：EASSR记录中获得三个主题和霍夫曼程序处理。可以评估在各种刺激速率下调制和未调制脉冲串的神经响应幅度增长函数和相位。针对抑制电伪影的三种不同插值方法的仿真表明，在0和1 ms之间的时间窗口中的正弦信号的插值已经证明对信号的频谱幅度的影响可以忽略不计，具有样条插值的上级性能。霍夫曼程序最初是为记录EASSR而开发的，其CI来自于制造商Cobriar，该程序已在MED-EL器械中得到验证。使用所述测量设置和制造商MED-EL的Cl记录EASSR是可行的。(C)2017爱思唯尔B. V.保留所有权利。
Background: Electrically evoked steady-state response (EASSR) recording is a measure of neuronal response strength after continuous electrical stimulation of the auditory system. In order to suppress the large electrical artifact generated by intracochlear electrical stimulation, a sophisticated artifact reduction processing strategy ("Hofmann procedure") has been proposed (Hofmann and Wouters, 2010). So far, EASSR recordings with artifact reduction procedures were reported only in cochlear implant (CI) users implanted with Cochlear devices (Macquarie, Australia).New method: Here, we demonstrate the application of the Hofmann procedure in CI users implanted with MED-EL (Innsbruck, Austria) devices. To demonstrate potential limitations of the procedure, we calculated discrete time Fourier transformations (DTFT) of various pulse patterns which may be used for EASSR.Results: EASSR recordings were obtained in three subjects and processed with the Hofmann procedure. Neural response amplitude growth functions and phase for modulated and unmodulated pulse trains at various stimulation rates could be assessed. Simulations of three different interpolation methods aimed to suppress the electrical artifact show that the interpolation of a sinusoidal signal in a temporal window between 0 and 1 ms has demonstrated negligible impact on the spectral amplitude of the signal with a superior performance of a spline interpolation.Comparison with existing method: The Hofmann procedure, initially developed for recording EASSRs with CIs from the manufacturer Cochlear, was validated for MED-EL devices.Conclusion: It is feasible to record EASSRs with the described measurement setup and Cls from the manufacturer MED-EL. (C) 2017 Elsevier B.V. All rights reserved.