Autonomic dysfunction is associated with brief episodes of atrial fibrillation in type 2 diabetes
Autonomic dysfunction is associated with brief episodes of atrial fibrillation in type 2 diabetes
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DOI：
10.1016/j.jdiacomp.2014.09.002
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发表时间：
2015-01-01
影响因子：
3
通讯作者：
Paolisso, Giuseppe
中科院分区：
文献类型：
--
作者：
Rizzo, Maria Rosaria;Sasso, Ferdinando Carlo;Paolisso, Giuseppe
背景和目标：本研究的目的是探讨无症状发作的心房颤动（AF）和自主神经系统异常的2型糖尿病患者谁没有证据，在baseline.Methods和结果之间的关系：在一个多中心的横断面对照研究，1992例2型糖尿病患者进行了筛选。所有患者均在3、6、9和12个月时进行了48小时的动态ECG记录。心率变异性（HRV）被用作自主活动的指标。入选176例有无症状房颤发作的糖尿病患者（SAFE组）和288例无无症状房颤发作的糖尿病患者（非SAFE组）。这些选定的糖尿病患者的临床和人体测量数据相匹配的120名对照组无糖尿病。HRV分析显示，在整个HM分析期间，SAFE组LF/HF比值均显著高于非SAFE组（P < 0.05）。AF绝对负荷与LF/HF比值呈正相关（r = 0.31，P < 0.001）。多元回归分析表明，LF/HF的比例是一个独立的决定因素AF episodes.Conclusions：这项研究最初表明，植物神经功能障碍和无症状房颤在2型糖尿病之间有很强的关系。(C)2015 Elsevier Inc. All rights reserved.
Background and Aims: This study aimed to investigate the relationship between asymptomatic episodes of atrial fibrillation (AF) and abnormalities of the autonomic nervous system in type 2 diabetic patients who did not have evidence of atrial fibrillation at baseline.Methods and Results: In a multicentric cross-sectional controlled study, 1992 patients with type 2 diabetes were screened. All underwent ambulatory ECG recording for 48-hour at 3, 6, 9, and 12 months. Heart rate variability (HRV) was used as indicator of autonomic activity. One hundred seventy-six diabetics with silent atrial fibrillation episodes (SAFE group) and 288 without silent atrial fibrillation (non-SAFE group) were enrolled. These selected diabetics were matched on clinical and anthropometric data to 120 control subjects without diabetes of the control group. HRV analysis evidenced that LF/HF ratio was significantly higher in the SAFE group than in the non-SAFE group (P < 0.05) in the whole period of HM analysis. AF absolute burdens were positively correlated with LF/HF ratio (r = 0.31, P < 0.001). Multiple regression analysis showed that LF/HF ratio was an independent determinant of AF episodes.Conclusions: This study originally showed a strong relationship between autonomic dysfunction and silent atrial fibrillation in type 2 diabetes. (C) 2015 Elsevier Inc. All rights reserved.