ANKYLOSING-SPONDYLITIS AND INFLAMMATORY BOWEL-DISEASE .2. PREVALENCE OF PERIPHERAL ARTHRITIS, SACROILIITIS, AND ANKYLOSING-SPONDYLITIS IN PATIENTS SUFFERING FROM INFLAMMATORY BOWEL-DISEASE
ANKYLOSING-SPONDYLITIS AND INFLAMMATORY BOWEL-DISEASE .2. PREVALENCE OF PERIPHERAL ARTHRITIS, SACROILIITIS, AND ANKYLOSING-SPONDYLITIS IN PATIENTS SUFFERING FROM INFLAMMATORY BOWEL-DISEASE
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DOI：
10.1136/ard.37.1.33
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发表时间：
1978-01-01
影响因子：
27.4
通讯作者：
TYTGAT, GNJ
中科院分区：
文献类型：
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作者：
DEKKERSAEYS, BJ;MEUWISSEN, SGM;TYTGAT, GNJ
为了确定炎症性肠病患者的外周关节炎、影像学骶髂炎和强直性脊柱炎的患病率，58例溃疡性结肠炎（UC）患者和51例克罗恩病（CD）患者进行了详细的风湿病检查。所有患者均接受HLA B27抗原筛查。外周性关节炎14例（UC 8例，CD 6例）（12.8%）；影像学诊断骶髂炎11例（5例UC， 6例CD）（10.1%），其中10例无症状；2例UC和2例CD诊断为强直性脊柱炎（3.7%）。18.9%的UC患者和3.9%的CD患者HLA B 27阳性。11例放射性脊柱炎患者中有1例，4例强直性脊柱炎患者中有2例具有HLA B27抗原。外周关节炎、放射性骶髂炎和强直性脊柱炎显然是炎症性肠病患者的常见表现。这些患者的无症状放射学骶髂炎在临床和遗传学上似乎与特发性强直性脊柱炎不同。对于强直性脊柱炎的诊断来说，主观风湿病主观性的评估是必要的，但在炎症性肠过程的突然发作时，很难进行评估，正如4例CD患者所示，他们的腰椎功能和胸部扩张明显受限，但SI关节没有放射学异常。
To establish the prevalence of peripheral arthritis, radiographic sacroliitis and ankylosing spondylitis in patients with inflammatory bowel disease, 58 consecutive patients suffering from ulcerative colitis (UC) and 51 with Crohn''s disease (CD) underwent a detailed rheumatological examination. All patients were screened for the presence of the antigen HLA B27. Peripheral arthritis was found in 14 (8 UC, 6 CD) patients (12.8%); radiographic sacroiliitis was diagnosed in 11 (5 UC, 6 CD) (10.1%), of whom 10 were asymptomatic; and ankylosing spondylitis was diagnosed in 2 UC and 2 CD patients (3.7%). A total of 18.9% of the UC and 3.9% of the CD patients were HLA B 27 positive. One of the 11 patients with radiographic sacroliitis and 2 of the 4 with ankylosing spondylitis had the HLA B27 antigen. Peripheral arthritis, radiographic sacroliitis and ankylosing spondylitis are apparently frequent manifestations in patients suffering from inflammatory bowel disease. Asymptomatic radiographic sacroiliitis in these patients appears to differ from idiopathic ankylosing spondylitis, both clinically and genetically. Evaluation of subjective rheumatological complaints, necessary for a confident diagnosis of ankylosing spondylitis, is difficult during a flare-up of the inflammatory bowel process, as was shown in 4 CD cases with marked limitation of lumbovertebral function and chest expansion, but no radiological abnormalities of the SI joints.