Lux vs. wavelength in light treatment of Seasonal Affective Disorder
Lux vs. wavelength in light treatment of Seasonal Affective Disorder
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DOI：
10.1111/j.1600-0447.2009.01345.x
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发表时间：
2009-09-01
影响因子：
6.7
通讯作者：
Lockley, S. W.
中科院分区：
文献类型：
--
作者：
Anderson, J. L.;Glod, C. A.;Lockley, S. W.
目的：已出版的治疗季节性情感障碍（SAD）的剂量指南涉及光通量，不适合短波长的光。短波长对光的许多非视觉反应是最有效的。如果SAD治疗是类似介导的，使用勒克斯的标准有高估必要剂量的风险。我们使用两个发光二极管（LED）光源来研究抗抑郁药对光的反应，每个光源都发射大量短波长光，但小于2500勒克斯。方法：一项随机双盲试验研究了18名中度抑郁症成年人（12岁，49.1±9.5岁）的3周45分钟/天的门诊治疗，使用蓝显（goLITE((R))）或富含蓝显的白光。在短波长范围内发射出相同数量的光子，但白色光源发射出的光子总数是白色光源的两倍，勒克斯是白色光源的七倍。结果：与基线相比，白光组和蓝光组的抑郁评分（sighg - ads; http://www.cet.org）平均下降82% (SD = 17%) （P < 0.0001）。两种来源的耐受性都很好。结论：与传统荧光光源相比，短波长的LED光源在较低的光通量下可有效治疗SAD。
Objective:Published dosing guidelines for treatment of Seasonal Affective Disorder (SAD) refer to photopic lux, which is not appropriate for short-wavelength light. Short wavelengths are most potent for many non-visual responses to light. If SAD therapy were similarly mediated, standards utilizing lux risk overestimating necessary dose. We investigated antidepressant responses to light using two light-emitting diode (LED) sources, each emitting substantial short-wavelength light, but < 2500 lux.Method:A randomized, double-blind trial investigated 3-week 45 min/day out-patient treatment with blue-appearing (goLITE((R))) or blue-enriched white-appearing light in 18 moderately-depressed adults (12F, 49.1 +/- 9.5 years). Equivalent numbers of photons within the short-wavelength range were emitted, but the white source emitted twice as many photons overall and seven-fold more lux.Results:Depression ratings (SIGH-ADS; http://www.cet.org) decrease averaged 82% (SD = 17%) from baseline (P < 0.0001) in both white- and blue-light groups. Both sources were well tolerated.Conclusion:Short-wavelength LED light sources may be effective in SAD treatment at fewer lux than traditional fluorescent sources.