Stimulation of esophageal mechanoreceptors is dependent on rate and duration of distension.
Stimulation of esophageal mechanoreceptors is dependent on rate and duration of distension.
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食管机械感受器的刺激取决于扩张的速度和持续时间。
DOI：
10.1152/ajpgi.1994.267.1.g115
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Castell,DO
中科院分区：
文献类型：
--
作者：
Nguyen,P;Castell,DO
我们随机比较了19名志愿者(男9名，女10名)的快速(170ml/S)和慢速(0.7ml/S)球囊扩张速度，使用位于下食道括约肌近端5 cm的乳胶球囊(长度3 cm)。在快速充气研究期间，气球充气/放气(1-S停留；5-10-S间隔)，在快速充气研究中，气球体积增加2毫升；在缓慢充气研究中，气球逐渐膨胀，而受试者盲目地表示感觉，等级如下：0(感觉不到)；1(感觉到气球，但没有不适)；2(疼痛或不适)。在第二组研究中，让气球向60 S充气，体积比产生感觉1的体积低2毫升，并记录时间，直到感觉发生变化。缓慢充气时感觉1的平均充气量为14.6±-1.2ml(SE)，快速充气时为8.5+/-0.8ml(P<；0.001)。缓慢充气组和快速充气组的平均充气量分别为23.7±-1.0ml和17.4±-1.0ml(P<；0.001)。随着持续的通货膨胀(60岁的S)，大多数受试者注意到越来越多的感觉，与最初的通货膨胀率无关。我们的结论是，远端食道感觉知觉(包括知觉和不适)依赖于机械感受器的刺激率。持续的扩张刺激似乎会招募更多的受体，并提高感觉意识的水平。
We randomly compared rapid (170 ml/s) and slow (0.7 ml/s) rates of balloon distension in 19 volunteers (9 male, 10 female) using a latex balloon (length 3 cm) positioned 5 cm proximal to the lower esophageal sphincter. The balloon was inflated/deflated (1-s dwell; 5- to 10-s interval) with increasing 2-ml volumes during rapid inflation studies and progressively distended during slow inflation studies while subjects blindly indicated feeling, rated as follows: 0 (no sensation); 1 (aware of balloon, but no discomfort); 2 (pain or discomfort). In a second set of studies, the balloon was left inflated for 60 s at a volume 2 ml below that producing sensation 1, and time until a change in sensation was recorded. This was repeated at a volume 2 ml below that producing sensation 2. Mean volume to sensation 1 with slow inflation was 14.6 +/- 1.2 ml (SE) and with rapid inflation was 8.5 +/- 0.8 ml (P < 0.001). Mean volume to sensation 2 with slow inflation was 23.7 +/- 1.0 ml and with rapid inflation was 17.4 +/- 1.0 ml (P < 0.001). With sustained (60 s) inflation, most subjects noted increasing sensation, independent of initial inflation rate. We conclude that distal esophageal sensory perception (both awareness and discomfort) is dependent on rate of stimulation of mechanoreceptors. A sustained distension stimulus appears to recruit additional receptors and increase the level of sensory awareness.