THE CLINICAL-PHARMACOLOGY AND DYNAMICS OF MARIHUANA CIGARETTE-SMOKING
THE CLINICAL-PHARMACOLOGY AND DYNAMICS OF MARIHUANA CIGARETTE-SMOKING
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DOI：
10.1002/j.1552-4604.1981.tb02596.x
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发表时间：
1981-01-01
影响因子：
2.9
通讯作者：
DIGUISEPPI, S
中科院分区：
文献类型：
--
作者：
PEREZREYES, M;OWENS, SM;DIGUISEPPI, S
我们研究了大麻吸烟的动力学，Δ9-四氢大麻酚（THC）的血浆浓度，以及以2小时间隔连续吸烟两支1%大麻香烟产生的药理作用。三名男性和三名女性，经验丰富的大麻吸烟者，参加了这项研究。结果表明，每个受试者以相似的速度吸了他或她的两支烟。第二支香烟的吸烟产生的THC血浆浓度略低于第一支香烟产生的浓度。由两种香烟引起的心理“高”水平是相似的。然而，第一支香烟使心脏加速的速度是第二支香烟的两倍。在男性和女性之间，吸烟的比例有显著差异。特别是，男性比女性吸得更多，吸得更频繁，吸得更快。THC的血浆浓度，自我报告的心理影响，以及吸烟两种香烟产生的心率加速在性别之间是相同的。
We have studied the dynamics of marihuana smoking, the plasma concentration of Δ9‐tetrahydrocannabinol (THC), and the pharmacologic effects produced by the sequential smoking of two 1% marihuana cigarettes at a 2‐hour interval. Three males and three females, experienced marihuana smokers, participated in the study. The results indicate that each subject smoked his or her two cigarettes at a similar rate. The THC plasma concentrations produced by the smoking of the second cigarette were slightly lower than those produced by the first cigarette. The levels of the psychologic “high” caused by the two cigarettes were similar. However, the first cigarette accelerated the heart twice as much as the second cigarette. Between males and females there were marked differences in the rate at which the cigarettes were smoked. In particular, males took more puffs, took them more often, and consumed the cigarettes more rapidly than females. The plasma concentrations of THC, the self‐reported psychologic effects, and the heart rate acceleration produced by the smoking of the two cigarettes were identical between the sexes.