Synthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7, and C-11 positions' substituent groups
Synthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7, and C-11 positions' substituent groups
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DOI：
10.1038/s41429-018-0064-9
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发表时间：
2018-09-01
影响因子：
3.3
通讯作者：
Omura, Satoshi
中科院分区：
文献类型：
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作者：
Goto, Kimihiko;Horikoshi, Ryo;Omura, Satoshi
对pyripyropene A的C-1、C-7和C-11位进行化学修饰以提高杀虫活性。一些衍生物对蚜虫表现出比pyripyropene A更高的杀虫活性。特别是在C-1、C-7和C-11位上具有三个环丙基羰基的衍生物5c在田间和实验室试验中具有优异的杀虫活性水平。
The C-1, C-7, and C-11 positions of pyripyropene A were chemically modified to improve the insecticidal activity. Some derivatives showed higher insecticidal activities against aphids than pyripyropene A. In particular, the derivative 5c, which possesses three cyclopropyl carbonyl groups at the C-1, C-7, and C-11 positions, had excellent insecticidal activity levels in field and laboratory trials.