Microbiome, inflammation, and cancer.
Microbiome, inflammation, and cancer.
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DOI：
10.1097/ppo.0000000000000048
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Grivennikov SI
中科院分区：
文献类型：
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作者：
Francescone R;Hou V;Grivennikov SI
长期以来，人们一直怀疑炎症在癌症的发病机制中起着重要作用。然而，直到最近，它的促癌作用的一些机制才被揭示。微生物，无论是共生的还是致病的，都是宿主免疫系统的关键调节器，最终是炎症的调节器。因此，微生物也有可能通过多种途径影响肿瘤的进展，包括炎症的慢性激活、肿瘤微环境的改变、基因毒性反应的诱导和代谢。在这篇综述中，我们将提供共生微生物区系、炎症和癌症的一般概述，以及微生物如何适应这一新兴领域。
Inflammation has long been suspected to play a major role in the pathogenesis of cancer. Only recently however, have some mechanisms of its tumor promoting effects come to light. Microbes, both commensal and pathogenic, are critical regulators of the host immune system, and ultimately, of inflammation. Consequently, microbes have the potential power to influence tumor progression as well, through a wide variety of routes, including chronic activation of inflammation, alteration of tumor microenvironment, induction of genotoxic responses, and metabolism. In this review, we will provide a general overview of commensal microbiota, inflammation and cancer, and how microbes fit into this emerging field.