Cerebral cortical thickness in patients with type 2 diabetes
Cerebral cortical thickness in patients with type 2 diabetes
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DOI：
10.1016/j.jns.2010.08.048
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发表时间：
2010-12-15
影响因子：
4.4
通讯作者：
Biessels, Geert Jan
中科院分区：
文献类型：
--
作者：
Brundel, Manon;van den Heuvel, Martijn;Biessels, Geert Jan
Objective: Type 2 diabetes mellitus (T2DM) is associated with cortical atrophy on MRI. It is unclear whether this atrophy is global or if there are areas with particular vulnerability. We compared regional cortical atrophy between patients with T2DM and controls and examined determinants of atrophy within the T2DM group.Methods: Cortical surface, volume and thickness were compared between 56 patients with T2DM and 30 controls, both globally and regionally, using the Freesurfer software package. The relationship between atrophy and HbA1c levels, diabetes duration, hypertension, a history of macrovascular disease and cerebral small vessel disease was analyzed within the T2DM group, with linear regression analyses, adjusted for age and gender.Results: Total cortical surface, total cortical volume and mean cortical thickness for both hemispheres were consistently lower in the T2DM group (between group differences: 0.5-4%), but the effects were only significant in the right hemisphere (p
