Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses.
Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses.
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DOI：
10.1038/emi.2013.28
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发表时间：
2013-05
影响因子：
13.2
通讯作者：
Lan, Ke
中科院分区：
文献类型：
--
作者：
Han, Jiankang;Niu, Furong;Jin, Meihua;Wang, Lili;Liu, Jia;Zhang, Peng;Xie, Bo;Wu, Xiaofang;Wen, Dong;Ji, Lei;Liu, Guangtao;Yang, Zhongrong;Zhang, Chiyu;Zhou, Dongming;Leng, Qibin;Lan, Ke
近日，一种新型H7N9禽流感甲型病毒导致中国暴发人流感。本文报道浙江省湖州市一名可能有慢性支气管炎病史的老人死于H7N9病毒。患者在发病前曾接触过家禽。血凝素和神经氨酸酶基因的系统发育分析显示，来自患者的病毒与他走访的家禽摊位的病毒之间存在密切的遗传关系，表明患者可能接触了受感染的家禽。两名家禽供应商和患者的密切接触者H7N9呈阴性，这表明有一些未知的机制可以防止他们感染新型H7N9病毒。此外，我们在血凝素的受体结合部位发现了5个新的H7N9病毒特异性序列变异，这可能与获得感染人类的能力有关。
Recently, a novel H7N9 avian influenza A virus has led to a human influenza outbreak in China. Here we report a 64-year old man with possible history of chronic bronchitis died from the H7N9 infection in Huzhou City, Zhejiang Province in Eastern China. The patient had been exposed to poultry before disease onset. Phylogenetic analyses of hemagglutinin and neuraminidase genes showed a close genetic relationship between viruses from the patient and from poultry booths where he had visited, indicating that the patient may have been exposed from the infected poultry. Two poultry venders and close contacts of the patient were negative for H7N9, suggesting that there are some unknown mechanisms to prevent them from being infected by the novel H7N9 virus. Furthermore, we found five novel H7N9 virus-specific sequence variations in receptor-binding site of hemagglutinin, which may be associated with the acquisition of the ability to infect humans.
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