Severely Depressed Young Patients Have Over Five Times Increased Risk for Stroke: A 5-Year Follow-Up Study
Severely Depressed Young Patients Have Over Five Times Increased Risk for Stroke: A 5-Year Follow-Up Study
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DOI：
10.1016/j.biopsych.2008.07.006
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发表时间：
2008-11-15
影响因子：
10.6
通讯作者：
Tsai, Shang-Ying
中科院分区：
文献类型：
--
作者：
Lee, Hsin-Chien;Lin, Herng-Ching;Tsai, Shang-Ying
背景资料：本研究旨在评估18岁至约44岁因抑郁症住院的年轻患者在出院后5年内发生卒中的风险。方法：我们的研究设计包括一个研究队列和一个比较队列。研究队列包括年龄在18岁至44岁之间的患者，他们因抑郁症的主要诊断而住院（n = 827），而对照队列包括随机选择的4，135名患者（每名抑郁症患者5名），并在性别、年龄和出院日期方面与研究组相匹配，每例患者在1998年出院后跟踪5年。考克斯比例风险回归计算5年无卒中生存率调整后可能的混杂factors.Results：在5年的随访期间，50例抑郁症患者（6.05%的研究队列）和48例非抑郁症受试者（1.16%的比较队列）发展中风。脑卒中的校正危险度为5.43（95%可信区间3.47-8.51，p <0.001）倍以上的抑郁症患者比非抑郁症受试者。我们的研究结果显示，18岁至44岁左右因抑郁症住院的年轻患者在出院后5年内发生中风的风险是非抑郁年龄患者的5倍以上，和性别匹配的实验对象
Background: This study aims to estimate the risk of developing stroke within 5 years of discharge among young patients ages 18 to approximately 44 who were hospitalized for depressive disorders.Methods: Our study design features a study cohort and a comparison cohort. The study cohort included patients ages 18 to approximately 44 who were hospitalized with a principal diagnosis of depressive disorder (n = 827), whereas the comparison cohort consisted of 4,135 patients selected randomly (five for every depressed patient) and matched with the study group in terms of gender, age, and date of discharge, Each patient was tracked for 5 years after their discharge in 1998. Cox proportional hazard regressions were performed to compute the 5-year stroke-free survival rates after adjusting for possible confounding factors.Results: During the 5-year follow-up period, 50 depressed patients (6.05% of the study cohort) and 48 non-depressed subjects (1.16% of the comparison cohort) developed strokes. The adjusted hazard of stroke was 5.43 (95% confidence interval 3.47-8.51, p < .001) times greater for depressed patients than for non-depressed subjects.Conclusions: Our findings show young patients ages 18 to approximately 44 who were hospitalized for depressive disorders were at over five times greater risk of developing stroke within 5 years of discharge compared with non-depressed age- and gender-matched subjects.