A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies
A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies
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DOI：
10.1128/jvi.02779-15
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发表时间：
2016-02-01
影响因子：
5.4
通讯作者：
Finzi, Andres
中科院分区：
文献类型：
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作者：
Ding, Shilei;Veillette, Maxime;Finzi, Andres
先前的研究表明，hiv -1感染个体的血清中含有能够介导抗体依赖性细胞毒性（ADCC）的抗体。这些抗体优先识别CD4结合诱导的包膜糖蛋白（Env）表位。在这里，我们发现gp120内结构域69位高度保守的色氨酸对抗a簇抗体和hiv -1感染者血清介导的ADCC很重要。
Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.