FDG-PET/CT finding of high uptake in pulmonary alveolar microlithiasis
FDG-PET/CT finding of high uptake in pulmonary alveolar microlithiasis
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DOI：
10.1007/s12149-007-0039-6
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发表时间：
2007-09-01
影响因子：
2.6
通讯作者：
Sasao, Yuki
中科院分区：
文献类型：
--
作者：
Ito, Kimiteru;Kubota, Kazuo;Sasao, Yuki
肺泡微石症是一种罕见的肺部疾病，其特征是肺泡内进行性钙化。我们提出一个PAM的情况下，异常积累的F-18-氟脱氧葡萄糖（FDG）在双肺。一名55岁的男子被转介到我们医院进行性呼吸困难。他在25年前通过经支气管肺活检被诊断为PAM。高分辨率计算机断层扫描显示多个致密钙化，肺内几乎没有充气。使用F-18-FDG的正电子发射断层扫描和计算机断层扫描（FDG-PET/CT）显示两肺中FDG异常蓄积，最大标准化摄取值为7.3。高FDG摄取主要在肺区域观察到，显示稀疏钙化。一个月后，患者死于呼吸衰竭，尸检显示两肺均无明显炎症变化。我们怀疑肺FDG摄取的显著增强可能与PAM的病理生理学有关。
Pulmonary alveolar microlithiasis (PAM) is a rare lung disease characterized by progressive intra-alveolar calcification. We present a case of PAM with abnormal accumulation of F-18-fluorodeoxyglucose (FDG) in both lungs. A 55-year-old man was referred to our hospital for progressive dyspnea. He had been diagnosed with PAM 25 years earlier by transbronchial lung biopsy. High-resolution computed tomography revealed multiple dense calcifications with little aerated lung. Combined positron emission tomography and computed tomography using F-18-FDG (FDG-PET/CT) showed the abnormal accumulation of FDG in both lungs with a maximal standardized uptake value of 7.3. High FDG uptake was observed mainly in the lung regions showing sparing calcification. The patient died of respiratory failure a month later and an autopsy revealed no significant inflammatory changes in either lung. We suspect that the markedly enhanced pulmonary FDG uptake may have some relation to the pathophysiology of PAM.