Skin-inspired, open mesh electrochemical sensors for lactate and oxygen monitoring
Skin-inspired, open mesh electrochemical sensors for lactate and oxygen monitoring
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DOI：
10.1016/j.bios.2019.02.041
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发表时间：
2019-05-01
影响因子：
12.6
通讯作者：
Koh, Ahyeon
中科院分区：
文献类型：
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作者：
Ashley, Brandon K.;Brown, Matthew S.;Koh, Ahyeon
可穿戴电子产品的研究为下一代技术铺平了道路，该技术旨在创建护理点生物传感器，该传感器将生物相容性平台上的联合收割机化学传感与人类健康监测的广泛应用相结合。尽管取得了重大进展，但皮肤和电子器件之间存在的微空间机械失配和不透流体界面在设备层压、保形性和长期监测中产生了附加问题。在此，我们设计了一种皮肤启发的，确定性图案化的电化学生物传感器，其可以与人体的曲线表面完全集成，同时机械地适应施加到皮肤上的自然应力并允许气体和流体的传质。特别是，我们开发了机械兼容的晶格结构的生物传感器，用于连续评估乳酸和氧气。传感器性能的系统研究进行了评估，在聚合物膜的变化和它的能力，以承受常见的苛刻，多轴向应力。
Research in wearable electronics has paved the way for next-generation technology, sought to create point-of care biosensors that combine chemical sensing on a biocompatible platform with a broad range of applications in human health monitoring. Despite significant progress, the microspatial mechanical mismatch and fluid-impermeable interface presented between skin and the electronics create adscititious problems in device lamination, conformality, and long-term monitoring. Herein, we engineered a skin-inspired, deterministically patterned, electrochemical biosensor that can be fully integrated with the curvilinear surface of the human body, while mechanically adapting to the natural stresses applied to the skin and allowing the mass transfer of gas and fluids. In particular, we developed mechanically-compliant lattice-structured biosensors for the continuous evaluation of lactate and oxygen. Systematic studies of the sensor performance were evaluated with variations in polymeric membranes and its ability to withstand commonplace harsh, multiaxial stresses.