Dual contrast enhanced magnetic resonance imaging of the liver with superparamagnetic iron oxide followed by gadolinium for lesion detection and characterization
Dual contrast enhanced magnetic resonance imaging of the liver with superparamagnetic iron oxide followed by gadolinium for lesion detection and characterization
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DOI：
10.1053/crad.2000.0673
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发表时间：
2001-05-01
影响因子：
2.6
通讯作者：
Halpern, E
中科院分区：
文献类型：
--
作者：
Kubaska, S;Sahani, DV;Halpern, E
目的：氧化铁造影剂可用于病变检测，细胞外钆螯合物可用于病变表征。我们进行了一项研究，以确定连续使用氧化阿魏颗粒和钆(Gd)-DTPA的双重对比增强肝脏成像是否可以在相同的成像方案中进行。材料与方法：16例患者行肝脏双对比磁共振成像（MRT）评估已知/疑似局灶性病变，包括转移瘤（n = 5）、肝细胞癌（HCC, n = 3）、胆管癌（n = 1）和局灶性结节增生（FNH, n = 3）。获得氧化铁前后t1加权梯度回忆回波（GRE）和t2加权快速自旋回波（FSE）序列，gd - dtpa （0.1 mmol/kg）后多相动态t1加权非相GRE成像。图像由三名专家以盲法分析，使用三分制评分系统对氧化铁T1前和后图像的病变显著性以及读者对Gd-DTPA T1后图像表征肝脏病变的信心进行分析。结果：在这个小型研究队列中，氧化铁治疗前后T1-GRE图像的病变显著性无统计学差异。氧化铁的存在不会明显降低钆后序列的图像质量，也不会阻止肝脏病变的表征。结论：我们的研究结果表明，氧化铁增强成像后，gd增强肝脏MRI对局灶性肝脏病变的表征仍然是可能的。中华放射医学杂志，2001,11(3):481 - 481。
AIM: Iron oxide contrast agents are useful for lesion detection, and extracellular gadolinium chelates are advocated for lesion characterization. We undertook a study to determine if dual contrast enhanced liver imaging with sequential use of ferumoxides particles and gadolinium (Gd)-DTPA can be performed in the same imaging protocol.MATERIALS AND METHODS: Sixteen patients underwent dual contrast magnetic resonance imaging (MRT) of the liver for evaluation of known/suspected focal lesions which included, metastases (n = 5), hepatocellular carcinoma (HCC; n = 3), cholangiocharcinoma (n = 1) and focal nodular hyperplasia (FNH; n = 3). Pre- and post-iron oxide T1-weighted gradient recalled echo (GRE) and T2-weighted fast spin echo (FSE) sequences were obtained, followed by post-Gd-DTPA (0.1 mmol/kg) multi-phase dynamic T1-weighted out-of-phase GRE imaging. Images were analysed in a blinded fashion by three experts using a three-point scoring system for lesion conspicuity on pre- and post-iron oxide T1 images as well as for reader's confidence in characterizing liver lesions on post Gd-DTPA T1 images.RESULTS: No statistically significant difference in lesion conspicuity was observed on pre- and post-iron oxide T1-GRE images in this small study cohort. The presence of iron oxide did not appreciably diminish image quality of post-gadolinium sequences and did not prevent characterization of liver lesions.CONCLUSION: Our results suggest that characterization of focal liver lesion with Gd-enhanced liver MRI is still possible following iron oxide enhanced imaging. Radiology, 56, 410-415 (C) 2001 The Royal College of Radiology.