Social amnesia in mice lacking the oxytocin gene
Social amnesia in mice lacking the oxytocin gene
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DOI：
10.1038/77040
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发表时间：
2000-07-01
期刊：
影响因子：
30.8
通讯作者：
Winslow, JT
中科院分区：
文献类型：
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作者：
Ferguson, JN;Young, LJ;Winslow, JT
啮齿动物社会熟悉性的发展主要取决于嗅觉线索，并可能严重影响生殖成功（1，2）。研究人员已经操作性地定义了这种记忆，即在重复或长时间遇到同种时，嗅觉调查的可靠减少（3-6）。大脑催产素（OT）和加压素（AVP）似乎可以调节从父母照顾到配偶监护的一系列社会行为（7）。药理学研究表明，AVP给药可增强社会记忆（8-10），而OT给药可抑制或促进社会记忆，这取决于剂量、途径或范例（1，11 -13）。我们发现，催产素基因突变的雄性小鼠（Oxt（-/-））未能发展社会记忆，而野生型（Oxt（+/+））小鼠显示完整的社会记忆。嗅觉觅食和嗅觉习惯化任务的测量表明，非社会刺激的嗅觉检测是完整的Oxt（-/-）小鼠。在Morris水迷宫、Y迷宫中测量空间记忆和行为抑制。或习惯性的声音惊吓也似乎完好无损。用OT而不是AVP治疗可以挽救Oxt（-/-）小鼠的社会记忆，而用OT拮抗剂治疗则在Oxt（+/+）小鼠中产生了类似社会健忘症的效果。我们的数据表明，OT是必要的正常发展的社会记忆在小鼠和支持的假设，社会记忆有一个神经基础不同于其他形式的记忆。
The development of social familiarity in rodents depends predominantly on olfactory cues and can critically influence reproductive success(1,2). Researchers have operationally defined this memory by a reliable decrease in olfactory investigation in repeated or prolonged encounters with a conspecific(3-6). Brain oxytocin (OT) and vasopressin (AVP) seem to modulate a range of social behaviour from parental care to mate guarding(7). Pharmacological studies indicate that AVP administration may enhance social memory(8-10), whereas OT administration may either inhibit or facilitate social memory depending on dose, route or paradigm(1,11-13). We found that male mice mutant for the oxytocin gene (Oxt(-/-)) failed to develop social memory, whereas wild-type (Oxt(+/+)) mice showed intact social memory. Measurement of both olfactory foraging and olfactory habituation tasks indicated that olfactory detection of non-social stimuli is intact in Oxt(-/-) mice. Spatial memory and behavioural inhibition measured in a Morris water-maze, Y-maze. or habituation of an acoustic startle also seemed intact. Treatment with OT but not AVP rescued social memory in Oxt(-/-) mice, and treatment with an OT antagonist produced a social amnesia-like effect in Oxt(+/+) mice. Our data indicate that OT is necessary for the normal development of social memory in mice and support the hypothesis that social memory has a neural basis distinct from other forms of memory.