Dystonia in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
Dystonia in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
复制标题
帕金森病、多系统萎缩和进行性核上性麻痹中的肌张力障碍
DOI：
10.1212/wnl.40.10.1571
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发表时间：
1990
期刊：
影响因子：
9.9
通讯作者：
C. Marsden
中科院分区：
文献类型：
--
作者：
J. Rivest;N. Quinn;C. Marsden
Adult-onset dystonia-parkinsonism is a syndrome in search of a pathology. We therefore reviewed the literature on dystonic manifestations in autopsy-proven cases of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and idiopathic Parkinson's disease (PD). Only 6 of 140 autopsy reports of MSA remarked on the presence of dystonia in life, but personal observations suggest prominent antecollis may develop at some stage in up to of sufferers. Similarly, very few (15/118) clinicopathologic observations on PSP included convincing dystonic manifestations, in contrast to some clinical reports where blepharospasm and early limb dystonia were prominent. Virtually any form of focal and segmental dystonia may sometimes occur with clinically diagnosed PD, with occasional descriptions of hemidystonia-hemiparkinsonism. However, there is pathologic confirmation of this diagnosis in only 1 case. With many patients thought clinically to have PD proving pathologically to have another cause for their parkinsonism, the true frequency and the range of dystonic manifestations acceptable in PD remain unknown.
