Heart rate variability during waking and sleep in healthy males and females
Heart rate variability during waking and sleep in healthy males and females
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DOI：
10.1093/sleep/22.8.1067
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发表时间：
1999-12-15
期刊：
影响因子：
5.6
通讯作者：
Orr, WC
中科院分区：
文献类型：
--
作者：
Elsenbruch, S;Harnish, MJ;Orr, WC
目的：通过心率变异性分析，研究男性和女性在不同睡眠阶段的自主神经活动。设计：本研究采用2组（男性、女性）X 4种状态（清醒、第2阶段睡眠、第4阶段睡眠、快速眼动睡眠）混合设计和一个重复的受试者内部因素（即状态）。环境：这项研究在托马斯·n·林恩医疗保健研究所的睡眠实验室进行。参与者：24名健康成年人（14名女性和10名男性）。干预措施：nama测量和结果：所有参与者在睡眠前清醒和睡眠一晚期间进行多导睡眠图监测和心电图记录。对醒着、第二阶段睡眠、第四阶段睡眠和快速眼动睡眠期间15分钟的心跳间隔进行频谱分析。与非快速眼动睡眠相比，快速眼动睡眠导致高频（HF）频带功率降低，低频（LF）与高频（HF）之比显著升高。与女性相比，男性在快速眼动睡眠时LF/HF比值显著升高。与女性相比，男性在清醒时也表现出明显降低的高频波段功率。未发现与睡眠或性别相关的低频波段功率显著变化。结论：结果证实了从清醒到睡眠的自主神经活动的变化，在非快速眼动睡眠和快速眼动睡眠之间存在显著差异。这些变化主要是由于与阶段相关的迷走神经张力的改变。快速眼动睡眠的特点是交感优势增强，继发于迷走神经戒断。数据还表明，男性在清醒和睡眠期间的自主神经功能存在性别差异，清醒时迷走神经张力下降，而在快速眼动睡眠期间交感神经优势增强。
Objectives: The study goal was to investigate autonomic activity with heart rate variability analysis during different sleep stages in males and females.Design: The study utilized a 2 Groups (males, females) X 4 States (waking, stage 2 sleep, stage 4 sleep, rapid-eye movement sleep) mixed design with one repeated, within-subjects factor (i.e., state).Setting: The study was carried out in the sleep laboratory of the Thomas N. Lynn Institute for Healthcare Research.Participants: Twenty-four healthy adults (fourteen females and ten males).Interventions: NAMeasurements and Results: All participants underwent polysomnographic monitoring and electrocardiogram recordings during pre-sleep waking and one night of sleep. Fifteen-minute segments of bleat-to-beat heart rate intervals during waking, stage 2 sleep, stage 4 sleep, and REM sleep were subjected to spectral analysis. Compared to NREM sleep, REM sleep was associated with decreased high frequency (HF) band power, and significantly increased low frequency (LF) to (HF) ratio. Compared to females, males showed significantly elevated LF/HF ratio during REM sleep. Males also demonstrated significantly decreased HF band power during waking when compared to females. No significant sleep- or gender-related changes in LF band power were found.Conclusions: The results confirmed changes in autonomic activity from waking to sleep, with marked differences between NREM and REM sleep. These changes were primarily due to stage-related alterations in vagal tone. REM sleep was characterized by increased sympathetic dominance, secondary to vagal withdrawal. The data also suggested gender differences in autonomic functioning during waking and sleep, with decreased vagal tone during waking and increased sympathetic dominance during REM sleep in the males.