Anthocyans from fruits and vegetables - Does bright colour signal cancer chemopreventive activity?
Anthocyans from fruits and vegetables - Does bright colour signal cancer chemopreventive activity?
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DOI：
10.1016/j.ejca.2005.06.009
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发表时间：
2005-09-01
影响因子：
8.4
通讯作者：
Marczylo, T
中科院分区：
文献类型：
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作者：
Cooke, D;Steward, WP;Marczylo, T
水果和浆果的消费与降低患癌症的风险有关。水果和浆果中最丰富的类黄酮成分是引起强烈着色的花色素（即花青素、糖苷及其糖苷配基、花青素）。在这篇综述中，我们描述了流行病学证据暗示在人类的癌症预防活性的含花青素的食物，在啮齿动物模型与花青素或含花青素的水果/蔬菜提取物的化学预防研究的结果，和花青素的药理学特性。花青素已被证明在10（-6）-10（-4）M浓度范围内抑制恶性细胞存活并混淆许多致癌信号传导事件。花色素苷作为单一药剂、花色素苷混合物或浆果提取物食用后的药代动力学研究表明，花色素苷在人体血液中达到10（-8）-10（-7）M的水平。目前还不清楚这样的浓度是否足以解释抗癌作用，以及花青素本身是否发挥化学预防功效，或者它们是否需要水解成它们的糖苷酸对应物。目前可用的文献提供了诱人的提示，潜在的有用性的花色素或花色素的混合物作为癌症的化学预防干预。然而，进一步的研究是必要的，以帮助判断其临床发展的有利性。(c)2005 Elsevier Ltd.
Consumption of fruits and berries has been associated with decreased risk of developing cancer. The most abundant flavonoid constituents of fruits and berries are anthocyans (i.e. anthocyanins, glycosides, and their aglycons, anthocyanidins) that cause intense colouration. In this review, we describe epidemiological evidence hinting at the cancer preventive activity of anthocyan-containing foods in humans, results of chemoprevention studies in rodent models with anthocyans or anthocyan-containing fruit/vegetable extracts, and pharmacological properties of anthocyans. Anthocyanidins have been shown to inhibit malignant cell survival and confound many oncogenic signalling events in the 10(-6)-10(-4) M concentration range. Studies of the pharmacokinetics of anthocyanins after their consumption as single agents, anthocyanin mixtures or berry extracts suggest that anthocyanins reach levels of 10(-8)-10(-7) M in human blood. It is unclear whether such concentrations are sufficient to explain anticarcinogenic effects, and whether anthocyanins exert chemopreventive efficacy themselves, or if they need to undergo hydrolysis to their aglyconic counterparts. The currently available literature provides tantalising hints of the potential usefulness of anthocyans or anthocyan mixtures as cancer chemopreventive interventions. Nevertheless further studies are necessary to help adjudge the propitiousness of their clinical development. (c) 2005 Elsevier Ltd.