Comparative genomics of Anopheles gambiae and Drosophila melanogaster
Comparative genomics of Anopheles gambiae and Drosophila melanogaster
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DOI：
10.1016/j.gene.2004.02.038
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发表时间：
2004-05-26
期刊：
影响因子：
3.5
通讯作者：
Bernardi, G
中科院分区：
文献类型：
--
作者：
Jabbari, K;Bernardi, G
冈比亚按蚊和黑腹果蝇的基因组序列分析表明，按蚊的DNA比果蝇的DNA具有更大的异质性和更丰富的gc。整个按蚊基因组的基因浓度表现为gc -贫乏部分的基因浓度较低，gc -丰富部分的基因浓度增加3倍；这种基因密度梯度大约是果蝇的一半。内含子和侧翼序列的GC水平与对应基因的GC(3)值（第三密码子位置的GC水平）相关，斜率远低于统一；换句话说，大多数内含子和基因间序列的gc含量低于相应的GC3值。这些发现描述了双翅目动物的组成变化，因为它们与脊椎动物的主要变化有相似之处，因此引起了人们的兴趣。(C) 2004 Elsevier B.V.版权所有
A sequence analysis of the genomes of Anopheles gambiae and Drosophila melanogaster reveals that Anopheles DNA is more heterogeneous and GC-richer than Drosophila DNA. The gene concentration across the Anopheles genome is characterized by low levels in the GC-poor part of the genome and a 3-fold increase in the GC-richest part; this gene density gradient is approximately half that of Drosophila. GC levels of introns and flanking sequences are correlated with GC(3) values (GC levels of third codon positions) of the corresponding genes with slopes much lower than unity; in other words, most introns and intergenic sequences are less GC-rich than the corresponding GC3 values. These findings, which describe a compositional shift within Diptera, is of interest because of their parallels in the well studied major shift in vertebrates. (C) 2004 Elsevier B.V. All rights reserved.