Genomic expression discovery predicts pathways and opposing functions behind phenotypes
Genomic expression discovery predicts pathways and opposing functions behind phenotypes
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DOI：
10.1074/jbc.m302800200
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发表时间：
2003-06-27
影响因子：
4.8
通讯作者：
Farooq, K
中科院分区：
文献类型：
--
作者：
Fathallah-Shaykh, HM;He, B;Farooq, K
发现高度确定的基因表达状态可能会预测生物表型背后的基因功能。通过算法将 10 个脑膜瘤中 19,200 个 cDNA 的表达状态（上调或下调）与正常大脑进行比较，该算法每 192,000 个仅检测到 1 个错误测量；已发现364个基因。表达数据准确预测信号通路的激活并将基因功能与特定表型联系起来。脑膜瘤似乎通过扰乱促进相反功能的分子的平衡表达而获得异常表型。这些发现揭示了相互关联的基因，并提出了基因组表达发现在生命系统功能基因组学中的作用。
Discovering states of genetic expression that are true to a high degree of certainty is likely to predict gene function behind biological phenotypes. The states of expression (up- or down-regulated) of 19,200 cDNAs in 10 meningiomas are compared with normal brain by an algorithm that detects only 1 false measurement per 192,000; 364 genes are discovered. The expression data accurately predict activation of signaling pathways and link gene function to specific phenotypes. Meningiomas appear to acquire aberrant phenotypes by disturbing the balanced expression of molecules that promote opposing functions. The findings expose interconnected genes and propose a role of genomic expression discovery in functional genomics of living systems.