Hypothalamic Regulation of Brown Adipose Tissue Thermogenesis and Energy Homeostasis.
Hypothalamic Regulation of Brown Adipose Tissue Thermogenesis and Energy Homeostasis.
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DOI：
10.3389/fendo.2015.00136
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发表时间：
2015
影响因子：
5.2
通讯作者：
Bi S
中科院分区：
文献类型：
--
作者：
Zhang W;Bi S
肥胖和糖尿病在全世界以惊人的速度增加，但预防和治疗这些疾病的战略仍然不足。棕色脂肪组织（BAT）通过使用脂质和葡萄糖作为代谢燃料产生热量，对于寒冷保护是重要的。这种产热作用导致增加的能量消耗和显著的脂质/葡萄糖处置。此外，在白色脂肪组织（WAT）或米色细胞中也发现了BAT，它们也表现出类似于BAT的产热作用。这些数据提供了证据，表明BAT/米色细胞是对抗肥胖和糖尿病的潜在靶点。最近在成年人中发现的活跃的BAT和米色细胞进一步强调了这种潜力。越来越多的研究也表明，中枢神经系统在控制BAT产热和WAT布朗宁中的重要性。本文综述了中枢神经温度调节，特别是解决我们目前的理解的重要性下丘脑神经信号在BAT/米色产热和能量稳态的调节。
Obesity and diabetes are increasing at an alarming rate worldwide, but the strategies for the prevention and treatment of these disorders remain inadequate. Brown adipose tissue (BAT) is important for cold protection by producing heat using lipids and glucose as metabolic fuels. This thermogenic action causes increased energy expenditure and significant lipid/glucose disposal. In addition, BAT in white adipose tissue (WAT) or beige cells have been found and they also exhibit the thermogenic action similar to BAT. These data provide evidence indicating BAT/beige cells as a potential target for combating obesity and diabetes. Recent discoveries of active BAT and beige cells in adult humans have further highlighted this potential. Growing studies have also shown the importance of central nervous system in the control of BAT thermogenesis and WAT browning using animal models. This review is focused on central neural thermoregulation, particularly addressing our current understanding of the importance of hypothalamic neural signaling in the regulation of BAT/beige thermogenesis and energy homeostasis.