Differences in Pancreatic Cancer Incidence Rates and Temporal Trends Across Asian Subpopulations in California (1988-2015)
Differences in Pancreatic Cancer Incidence Rates and Temporal Trends Across Asian Subpopulations in California (1988-2015)
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DOI：
10.1097/mpa.0000000000001337
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发表时间：
2019-08-01
期刊：
影响因子：
2.9
通讯作者：
Setiawan, Veronica Wendy
中科院分区：
文献类型：
--
作者：
Liu, Lihua;Zhang, Juanjuan;Setiawan, Veronica Wendy
目的 胰腺癌 (PanCan) 发病率存在种族差异，但对异质亚裔美国人的发病趋势知之甚少。我们研究了详细种族人群（包括亚裔美国人亚群）中 PanCan 的发病率和时间模式。方法 1988 年至 2015 年间，加州癌症登记处共鉴定了 71,099 例侵袭性外分泌 PanCan 病例。这些病例被分为相互排斥的非西班牙裔 (NH) 白人、NH 黑人、西班牙裔、NH 亚洲/太平洋岛民 (API) 和 NH 美洲印第安人/阿拉斯加原住民 (AIAN) 组。亚洲人进一步被特定的种族所识别。结果 PanCan 的年龄调整发病率（AAIR，每 100,000 人）在不同种族/族裔群体中差异显着，最高为新罕布什尔州黑人 10.4，新罕布什尔州白人为 7.6，西班牙裔为 7.1，新罕布什尔州 API 为 6.2，最低为新罕布什尔州 AIAN 5.2。尽管 NH API 的比率相对较低，但亚洲亚组之间的比率差异很大，日本人 (8.1) 和韩国人 (7.5) 的比率与 NH 白人 (7.5) 相似，而南亚人 (4.4) 的比率较低。结论 分类亚裔美国人中 PanCan 发病率的显着异质性是一个新发现。这些结果填补了亚裔美国人 PanCan 负担的空白，并强调了癌症研究中分类种族人群的重要性。
Objective Ethnic disparities in pancreatic cancer (PanCan) incidence exist, but little is known about incidence trends in heterogeneous Asian Americans. We examined PanCan incidence and temporal patterns among detailed ethnic populations, including Asian American subgroups. Methods A total of 71,099 invasive exocrine PanCan cases were identified using the California Cancer Registry between 1988 and 2015. Cases were grouped into mutually exclusive groups of non-Hispanic (NH) white, NH black, Hispanic, NH Asian/Pacific Islander (API), and NH American Indian/Alaska Native (AIAN). Asians were further identified by specific ethnicity. Results The age-adjusted incidence rates (AAIRs, per 100,000) of PanCan varied significantly across racial/ethnic groups, ranging from the highest of 10.4 in NH blacks to 7.6 in NH whites, 7.1 in Hispanics, 6.2 in NH APIs, and to the lowest of 5.2 in NH AIAN. Despite the relatively low rate in the NH APIs, the rates across Asian subgroups varied significantly, with rates similar to NH whites in Japanese (8.1) and Koreans (7.5) to the low rate in South Asians (4.4). Conclusions Significant heterogeneity of PanCan incidence in disaggregated Asian Americans is a novel finding. These results fill a gap regarding PanCan burden in Asian Americans and underscore the importance of disaggregating ethnic populations in cancer research.