Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint
Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint
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DOI：
10.1016/j.bbr.2006.07.015
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发表时间：
2006-11-01
影响因子：
2.7
通讯作者：
Eyles, Darryl W.
中科院分区：
文献类型：
--
作者：
Burne, Thomas H. J.;O'Loan, Jonathon;Eyles, Darryl W.
出生前短暂的维生素D缺乏会导致成年大鼠多动症。本研究的目的是研究急性束缚对DVD大鼠和对照组大鼠在野外的行为的影响。在发育中维生素D(DVD)缺乏或完全(对照)的环境中孕育和出生的大鼠，在8周龄时，使用自动视频跟踪软件在开阔的田野中进行30分钟的监测。一半的大鼠在开场测试前立即被束缚在毛巾内5min。其余的在露天测试之前只接受了最低限度的处理。重复先前的发现，与对照大鼠相比，DVD缺乏的动物在开场测试的前10分钟内运动能力增强。相比之下，急性束缚应激后的运动活动没有差异。大鼠在旷野角落和边上停留的时间受产前饮食的影响。在整个30分钟的测试中，DVD大鼠在角落里呆的时间比对照组少，在边上呆的时间比对照组大鼠多。这种差异在急性束缚应激大鼠中看不到。在中心度过的时间不会因产前饮食或急性束缚而改变。因此，出生前短暂的维生素D缺乏会导致成年后短暂的自发性多动症，这是由急性束缚应激调节的。(C)2006爱思唯尔B.V.保留所有权利。
Transient prenatal vitamin D deficiency produces hyperlocomotion in the adult rat. The aim of this study was to examine the effects of acute restraint on the behaviour of DVD and control rats in the open field. Rats were conceived and born to developmentally vitamin D (DVD) deficient or replete (control) dams and, at 8 weeks of age, were monitored for 30 min in an open field using automated video tracking software. Half of the rats were restrained within a towel for 5 min immediately before the open field test. The remainder received minimal handling prior to the open field test. Repeating previous findings, DVD deficient animals had enhanced locomotion during the first 10 min of the open field test compared to control rats. By contrast, there were no differences in locomotor activity after acute restraint stress. The time rats spent in the corners and side of the open field was affected by prenatal diet. DVD rats spent less time in the corners and more time in the side than control rats across the whole 30 min test. This difference was not seen in rats with acute restraint stress. The time spent in the centre was not altered by prenatal diet or acute restraint. Thus, transient prenatal vitamin D deficiency induces a transient spontaneous hyperlocomotion in adulthood that is modulated by acute restraint stress. (c) 2006 Elsevier B.V. All rights reserved.