Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT).
Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT).
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DOI：
10.1371/journal.pone.0253064
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Bachoud-Lévi AC
中科院分区：
文献类型：
--
作者：
Lunven M;Hamet Bagnou J;Youssov K;Gabadinho A;Fliss R;Montillot J;Audureau E;Bapst B;Morgado G;Reilmann R;Schubert R;Busse M;Craufurd D;Massart R;Rosser A;Bachoud-Lévi AC
在亨廷顿病（HD）患者的小队列中，缺乏对纵向恶化敏感的有效认知任务。因此，我们开发并评估了数字化算术任务（DAT），该任务在大约4分钟内结合了内部语言和执行功能。我们在欧洲四个研究中心评估了77名早期HD患者（年龄：52 ± 11岁; 27名女性）和57名对照组（年龄：50 ± 10岁，31名女性）中三种语言的DAT的心理测量学特性。对48例HD患者和34例对照者进行了长达1年的随访，其中96例参与者在基线时接受了MRI脑成像（HD患者= 46），50例参与者（HD患者= 22）在1年时接受了MRI脑成像。使用线性混合模型和Pearson相关性评估与临床评估的相关性。在基线时，与对照组的DAT相比，HD患者的准确性较低（p = 0.0002），反应时间增加（p<0.0001）。HD患者的反应时间的重测信度范围从良好到极好（范围：0.63-0.79），准确性的范围从可疑到可接受（范围：r = 0.52-0.69）。只有DAT、Mattis痴呆评定量表、符号数字模式测试和总功能能力评分能够检测到HD患者在一年随访内的下降（所有p< 0.05）。与所有其他认知任务相比，DAT随时间推移与纹状体萎缩相关（p = 0.037），但与运动障碍无关。DAT快速、可靠、无运动，适用于多种语言，并且能够揭示HD患者小队列中与纹状体萎缩相关的认知下降。这可能使其成为未来HD和其他神经退行性疾病试验的有用终点。
Efficient cognitive tasks sensitive to longitudinal deterioration in small cohorts of Huntington’s disease (HD) patients are lacking in HD research. We thus developed and assessed the digitized arithmetic task (DAT), which combines inner language and executive functions in approximately 4 minutes. We assessed the psychometric properties of DAT in three languages, across four European sites, in 77 early-stage HD patients (age: 52 ± 11 years; 27 females), and 57 controls (age: 50 ± 10, 31 females). Forty-eight HD patients and 34 controls were followed up to one year with 96 participants who underwent MRI brain imaging (HD patients = 46) at baseline and 50 participants (HD patients = 22) at one year. Linear mixed models and Pearson correlations were used to assess associations with clinical assessment. At baseline, HD patients were less accurate (p = 0.0002) with increased response time (p<0.0001) when compared to DAT in controls. Test-retest reliability in HD patients ranged from good to excellent for response time (range: 0.63–0.79) and from questionable to acceptable for accuracy (range: r = 0.52–0.69). Only DAT, the Mattis Dementia Rating Scale, the Symbol Digit Modalities Test, and Total Functional Capacity scores were able to detect a decline within a one-year follow-up in HD patients (all p< 0.05). In contrast with all the other cognitive tasks, DAT correlated with striatal atrophy over time (p = 0.037) but not with motor impairment. DAT is fast, reliable, motor-free, applicable in several languages, and able to unmask cognitive decline correlated with striatal atrophy in small cohorts of HD patients. This likely makes it a useful endpoint in future trials for HD and other neurodegenerative diseases.
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影响因子：
9.9
作者：
Langbehn, Douglas R.;Paulsen, Jane S.
通讯作者：
Paulsen, Jane S.
影响因子：
9.9
作者：
Schobel, Scott A.;Palermo, Giuseppe;Tabrizi, Sarah J.
通讯作者：
Tabrizi, Sarah J.
影响因子：
2.5
作者：
Andin, Josefine;Fransson, Peter;Rudner, Mary
通讯作者：
Rudner, Mary
DOI：
10.1371/currents.rrn1288
发表时间：
2011-11-30
期刊：
PLoS currents
影响因子：
--
作者：
Hart E;Middelkoop H;Jurgens CK;Witjes-Ané MN;Roos RA
通讯作者：
Roos RA
影响因子：
3.7
作者：
Schramm C;Katsahian S;Youssov K;Démonet JF;Krystkowiak P;Supiot F;Verny C;Cleret de Langavant L;Bachoud-Lévi AC;European Huntington's Disease Initiative Study Group and the Multicentre Intracerebral Grafting in Huntington's Disease Group
通讯作者：
European Huntington's Disease Initiative Study Group and the Multicentre Intracerebral Grafting in Huntington's Disease Group