1H NMR relaxation times of skeletal muscle metabolites at 3 T
1H NMR relaxation times of skeletal muscle metabolites at 3 T
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DOI：
10.1007/s10334-003-0029-1
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发表时间：
2004-03-01
影响因子：
2.3
通讯作者：
Roden, M
中科院分区：
文献类型：
--
作者：
Krssak, M;Mlynárik, V;Roden, M
本研究报告了健康青年志愿者比目鱼肌和胫骨前肌中水和代谢物在3 T下的质子弛豫时间。结果与1.5 T和4 T的报告数据一致，表明水、肌酸和脂质的自旋-晶格弛豫时间随着B-0而稳定增加，并且B-0对自旋-自旋弛豫没有影响。肌肉之间的比较显示比目鱼肌比胫骨前肌更长的水的自旋-自旋松弛时间（31 +/- 1 ms对28 +/- 1 ms，p < 0.05）。这些数据可用于骨骼肌代谢物浓度绝对定量的弛豫校正和进一步的序列优化。
This study reports proton relaxation times of water and metabolites in soleus and tibialis anterior muscles of young healthy volunteers at 3 T. The results are in agreement with data reported for 1.5 and 4 T, showing a steady increase of spin-lattice relaxation times of water, creatine and lipids with B-0 and no effect of B-0 on spin-spin relaxation. Comparison between muscles revealed a longer spin-spin relaxation time of water in soleus than in tibialis anterior muscle (31 +/- 1 ms vs. 28 +/- 1 ms, p < 0.05). These data can be applied to relaxation correction for the absolute quantification of skeletal muscle metabolite concentrations and further sequence optimization.